抗菌肽及其模拟物的临床应用研究进展

发布时间：2018-01-11 03:15

本文关键词：抗菌肽及其模拟物的临床应用研究进展　出处：《中华损伤与修复杂志(电子版)》2016年02期 　论文类型：期刊论文

【摘要】：抗菌肽,作为一种新型的抗生素替代药物,近年来得到了极大关注。本文概述了抗菌肽及其模拟物的抗菌特性及优势特点,着重阐述了其临床研究进展和临床应用面临的挑战。抗菌肽具有不同于传统抗生素的独特抗菌机制,能够杀灭多重耐药菌且不易诱导产生抗药性,数十种抗菌肽已进入了临床试验阶段,但是毒性作用、不稳定性及成本昂贵使其临床应用受到限制。针对上述缺陷,研究者尝试合理改造抗菌肽的结构,并着手研发抗菌肽模拟物。相信在未来,抗菌肽及其模拟物会在对抗耐药菌方面发挥重要的作用。
[Abstract]:Antimicrobial peptides, as a new antibiotic substitute, have received great attention in recent years. In this paper, the antibacterial characteristics and advantages of antimicrobial peptides and their mimics are summarized. The progress in clinical research and the challenges in clinical application are emphasized. Antimicrobial peptides have a unique antibacterial mechanism different from traditional antibiotics, which can kill multidrug resistant bacteria and are not easy to induce drug resistance. Dozens of antimicrobial peptides have entered the stage of clinical trials, but the toxicity, instability and high cost limit their clinical application. In view of the above defects, the researchers try to modify the structure of antimicrobial peptides reasonably. It is believed that antimicrobial peptides and their mimics will play an important role in antimicrobial resistance in the future.
【作者单位】：第二军医大学附属长海医院烧伤外科全军烧伤研究所;
【基金】：中国工程院咨询研究项目(2015-XY-26)
【分类号】：R978.1
【正文快照】： 近年来,烧创伤病房内的细菌耐药情况愈发严峻[1-2]。大面积难愈性创面、合并吸入性损伤、气管切开与机械通气、深静脉置管、留置导尿等都易导致多重耐药菌的感染,而传统抗生素逐渐失去了理想疗效,这为烧创伤患者的感染救治带来了很大挑战[3]。因此,新型抗菌药物的研发已迫在眉

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