醇质体在经皮给药系统中的应用研究

发布时间：2018-01-14 20:12

本文关键词：醇质体在经皮给药系统中的应用研究　出处：《中国药房》2017年28期 　论文类型：期刊论文

【摘要】：目的:为醇质体在经皮给药系统中的应用提供参考。方法:以"醇质体""经皮给药""醇质体制备""Ethosomes""Transdermal drug delivery""Preparation of ethosomes"等为关键词,组合查询2000年1月-2017年5月在中国知网、PubMed、Elsevier、Springer等数据库中的相关文献,对影响醇质体经皮渗透的因素和醇质体的理化性质、制备方法、经皮吸收特点以及其毒性等方面进行综述。结果与结论:共检索到相关文献342篇,其中有效文献32篇。醇质体是由磷脂、高浓度醇、水构成的新型载药体系,其中醇能使醇质体流动性增强,磷脂能使醇质体更易穿过皮肤角质层;与脂质体比较,醇质体流动性更好、粒径更小、Zeta电位更低、稳定性更高、包封率更高。醇质体的制备方法简单,常用的方法有注入法、注入-超声结合法、薄膜分散法、pH梯度法。醇质体经皮渗透速率、药物经皮渗透累积量、药物在皮肤中滞留量较其他剂型显著提高;醇质体对皮肤无毒、无刺激。现已有盐酸苯海索、补骨脂素、熊果苷、芹菜素、氯诺昔康、睾酮、红霉素、利多卡因、栀子苷等药物的醇质体应用于经皮给药中。目前关于醇质体的研究很多还只是停留在简单的制备工艺、透皮吸收等实验阶段,而关于处方组成及比例对醇质体理化性质和透皮吸收效果的影响报道较少;关于醇质体皮肤滞留量的研究,多取自透皮吸收实验结束的时间点,缺乏动态的研究;有关醇质体的透皮吸收机制研究也不足。今后应从以上几方面着手,加强醇质体的基础研究。
[Abstract]:Objective: to provide a reference for the application of alcoholplasts in the transdermal drug delivery system. Methods: to prepare "Ethosomes" "Transdermal" from "alcoholplasts" and "transdermal administration". Drug delivery "" Preparation of ethosomes "etc. The related documents were collected from January 2000 to May 2017 in the database of PubMedus Elsevier Springer and other databases in China. Factors affecting transdermal permeation of alcoholplasts, physicochemical properties, preparation methods, characteristics of percutaneous absorption and toxicity of alcoholplasts were reviewed. Results and conclusion: 342 references were retrieved. Among them, 32 effective papers. Altoplast is a new drug delivery system composed of phospholipid, high concentration alcohol and water, in which alcohol can enhance the fluidity of alcohols, and phospholipid can make the alcoholplast pass through the skin keratinocytes more easily. Compared with liposomes, alcohols have better fluidity, lower Zeta potential, higher stability and higher entrapment efficiency. The transdermal permeation rate of alcoholplast, the accumulation of drug permeation through skin, and the drug retention in the skin were significantly higher than those in other formulations. The glycosomes are nontoxic and nonirritating to the skin. Phenohydrin hydrochloride, psoralen, arbutin, apigenin, lornoxicam, testosterone, erythromycin, lidocaine have been found. Geniposide and other drugs used in transdermal delivery of alcoholplasts. At present, many of the studies on alcoholplasts are still in the simple preparation process, transdermal absorption and other experimental stages. However, there were few reports on the effects of prescription composition and proportion on the physicochemical properties and transdermal absorption of alcohols. Most of the studies on the skin retention of alcoholplasts are taken from the time point at the end of the transdermal absorption experiment, and lack of dynamic research. The study on the mechanism of transdermal absorption of alcoholplasts is also insufficient. In the future, we should strengthen the basic research of alcoholplasts from the above aspects.
【作者单位】：天津中医药大学中药学院;天津嘉氏堂科技有限公司;天津中医药大学附属保康医院药剂科;
【基金】：国家自然科学基金资助项目(No.81602773) 天津市西青区科技型中小企业发展专项资金项目(No.XQKH2013-011)
【分类号】：R943
【正文快照】： 经皮药物传递系统(Transdermal drug delivery sys-tem,TDDS),是继口服、注射之后的第三大给药系统,能绕过肝首关效应,避免药物在胃肠道被破坏,具有减少血药浓度波动、降低毒副反应、方便用药、患者依从性好等优点[1]。但TDDS在实际应用中常遇到药物难以吸收或吸收缓慢的问题,

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