头孢硫脒在小鼠的药动学研究

发布时间：2018-01-15 18:36

  本文关键词：头孢硫脒在小鼠的药动学研究　出处：《中国抗生素杂志》2015年05期 　论文类型：期刊论文

  更多相关文章： 头孢硫脒 药动学 LC-MS/MS 血浆

【摘要】：目的研究头孢硫脒在小鼠中的药动学。方法取24只小鼠,随机分为4组,每组6只,分别静脉给予7.3、29.2、116.8和467.6mg/kg的头孢硫脒,采集不同时间点的血样,分离血浆,使用经过确证的LC-MS/MS方法测定血浆中头孢硫脒的浓度,用Win Nonlin软件中的非房室模型计算药动学参数。结果静脉给药后,获得的主要药动学参数如下:T1/2分别为(0.20±0.03)、(0.33±0.05)、(0.27±0.08)和(0.38±0.10)h;AUC0~∞分别为(2.85±0.63)、(11.31±1.71)、(53.38±17.57)和(374.9±134.7)h·mg/L;Cmax值分别为(9.53±2.10)、(46.67±9.50)、(170.18±71.02)和(1004.0±166.2)mg/L。结论本文建立了快速、灵敏测定小鼠血浆中头孢硫脒的LC-MS/MS方法,并用于头孢硫脒在小鼠中的药动学研究。药动学结果显示,该药体内消除很快,不同剂量间的药动学参数呈现比较明显的相关关系。
[Abstract]:Objective to study the pharmacokinetics of cefathiramidine in mice. Methods 24 mice were randomly divided into 4 groups with 6 rats in each group. 116.8 and 467.6 mg / kg cefathiamidine were collected, blood samples were collected at different time points, plasma was isolated, and the concentration of cefathiamidine in plasma was determined by confirmed LC-MS/MS method. The pharmacokinetic parameters were calculated by using the non-atrioventricular model of Win Nonlin software. Results after intravenous administration, the main pharmacokinetic parameters were as follows: T1 / 2 was 0.20 卤0.03). (0. 33 卤0. 05) and 0. 38 卤0. 10 hs, 0.27 卤0. 08) and 0. 38 卤0. 10 hs respectively. The AUC _ 0 ~ 鈭，

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