微喷射给药的力学分析和实验研究

发布时间：2018-01-16 00:25

本文关键词：微喷射给药的力学分析和实验研究　出处：《杭州电子科技大学》2014年硕士论文　论文类型：学位论文

【摘要】：随着时代的发展，传统的给药方式逐渐满足不了特定群体以及特殊场合的注射需求。由于无针给药较传统给药系统具有无可比拟的优势，已成为当代新型药物输送系统研究的热点。为了突破皮肤屏障进行药物高效吸收，研究人员开发出基于各种动力源的无针注射技术，并进行临床应用研究。本文对基于音圈电机驱动的无针注射技术和药物在皮肤的吸收情况进行深入研究。研究内容分成相对独立的两部分：第一部分针对传统无针注射系统的复杂以及不可调控性，设计了一种基于音圈电机驱动的新型无针注射系统，该系统具有结构简单、可控的特性，最后对直线音圈电机三维建模导入磁场分析软件对电机磁场和力进行分析；本文第二部分分析了皮肤组成并简要介绍皮肤的机械性能，构建了基于微喷射给药穿透皮肤屏障进而被人体吸收的数学模型，为以后的微喷射给药系统的研发提供借鉴意义。论文总共分为6章，各章主要内容如下：第1章，，阐述了课题研究的背景和意义，详细介绍了微喷射给药系统和药物经皮吸收的国内外研究现状，并提出了本文研究的主要内容。第2章，设计了一种基于音圈电机驱动的无针系统，其中包括音圈电机的机械结构设计和控制电路设计。第3章，对直线音圈电机进行三维建模并使用电磁场有限元分析软件ANSOFT进行磁场和力分析。对基于无针注射系统在体外的喷射注射机理进行了理论研究，建立了微喷射给药过程中喷射压强与系统参数(如微型喷孔直径、腔体尺寸、音圈电流等)之间的理论模型。第4章，介绍人体皮肤的构成以及机械特性，在国外专家研究的基础上进一步建立微喷射流刺穿人体皮肤的模型。最后针对药物在真皮层中药物的吸收过程进行数学建模。第5章，搭建微喷射流压强的检测系统，检测微喷射流的压强并与理论压强进行对比分析。第6章，对全文进行总结，指出该研究内容创新之处，并提出该无针注射系统还存在的问题以及微喷射给药的药物经皮吸收模型的不足之处以及改进方向。
[Abstract]:With the development of the times, the traditional drug delivery methods can not meet the specific needs of specific groups and special occasions. Because of the needle free drug delivery system than the traditional drug delivery system has an unparalleled advantage. In order to break through the skin barrier for drug absorption, researchers have developed needle free injection technology based on various power sources, and carried out clinical application research. In this paper, the needle-less injection technology driven by voice coil motor and the absorption of drugs in the skin were studied in depth. The research was divided into two parts:. The first part is aimed at the complexity and irregulability of the traditional needle-free injection system. A new needle-less injection system driven by voice coil motor is designed. The system has the characteristics of simple structure and controllable structure. Finally, the magnetic field and force of linear voice coil motor are analyzed by introducing magnetic field analysis software into 3D modeling of linear voice coil motor. In the second part of this paper, the composition of skin was analyzed and the mechanical properties of skin were briefly introduced, and a mathematical model based on microspray was established to penetrate the skin barrier and then be absorbed by human body. For the future research and development of micro-injection drug delivery system to provide reference. The thesis is divided into six chapters. The main contents of each chapter are as follows: In chapter 1, the background and significance of the research are described, and the research status of microinjection drug delivery system and drug transdermal absorption are introduced in detail, and the main contents of this study are put forward. In chapter 2, a needleless system based on voice coil motor is designed, which includes mechanical structure design and control circuit design of voice coil motor. Chapter 3. The 3D modeling of linear voice coil motor and the magnetic field and force analysis using the electromagnetic field finite element analysis software ANSOFT were carried out. The injection mechanism in vitro based on the needle free injection system was studied theoretically. A theoretical model between the injection pressure and system parameters (such as the diameter of the micro-hole, the size of the cavity, the current of the voice coil, etc.) was established. Chapter 4 introduces the composition and mechanical characteristics of human skin. On the basis of foreign experts' research, the model of microjet piercing human skin was established. Finally, the mathematical model of drug absorption in the dermis was established. In chapter 5, the pressure detection system of micro jet jet is built, and the pressure of micro jet jet is measured and compared with the theoretical pressure. Chapter 6 summarizes the whole paper, points out the innovation of the research content, and points out the problems existing in the needle free injection system, the shortcomings of the drug percutaneous absorption model of microinjection and the direction of improvement.
【学位授予单位】：杭州电子科技大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R962

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