口服缓控释系统的研究进展

发布时间：2018-01-16 17:17

本文关键词：口服缓控释系统的研究进展　出处：《中国药房》2015年16期 　论文类型：期刊论文

【摘要】：目的:综述口服缓控释系统的研究进展。方法:以"骨架片""渗透泵片""纳米技术""缓控释制剂"等为关键词,在Elsevier期刊、清华大学镜像、相关期刊论文等检索源检索相关文献,筛选2009-2014年口服缓控释系统的释药机制、剂型及制备技术等研究进行综述。结果:共检索到相关文献651 055篇,其中有效文献237篇。口服缓控释制剂的释药机制主要有扩散、溶蚀、溶出、渗透泵和离子交换等,常用剂型有骨架片、渗透泵片、胃滞留制剂、结肠定位制剂、定时脉冲胶囊等,最新的制备技术有纳米制剂技术、靶向制剂技术、固体分散技术和半固体制剂技术等。结论:口服缓控释系统的研究与开发已经成为缓控释制剂发展的一个重要方向,但作为一种新型给药系统仍需进一步研究。
[Abstract]:Objective: to review the research progress of oral controlled release system. Methods: "skeleton tablets", "osmotic pump tablets", "nanotechnology" and "slow controlled release preparations" were used as keywords in Elsevier journals. The mirror image of Tsinghua University, the full text database of Chinese periodicals and other retrieval sources were used to search the relevant literature, and to screen the drug release mechanism of the oral controlled release system for 2009-2014. Results: a total of 651,055 related literatures were retrieved, of which 237 were effective. The drug release mechanisms of oral controlled release preparations were mainly diffusion, dissolution and dissolution. Osmotic pump and ion exchange, the commonly used dosage forms are skeleton tablets, osmotic pump tablets, stomach retention preparations, colon positioning preparations, timing pulse capsules, etc. The latest preparation technology has nanometer preparation technology, targeted preparation technology. Conclusion: the research and development of oral controlled release system has become an important direction in the development of slow release preparation, but as a new drug delivery system, it needs further study.
【作者单位】：青岛科技大学制药工程系;
【基金】：山东省科技发展计划项目(No.2012GNC11307)
【分类号】：R944
【正文快照】： 口服缓控释系统系指口服后有目的地延缓、控制药物释放以达到合理治疗效果的一类新型给药系统,其制剂称为口服缓控释制剂。自20世纪50年代末以来,随着现代药物制剂技术的发展,口服缓控释制剂的理论和技术也日趋成熟,一些药物已可以通过适宜的制剂手段制成释药相对平稳的口服缓

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