Tween-80的化学组分与其溶血作用的关系

发布时间：2018-01-18 06:04

本文关键词：Tween-80的化学组分与其溶血作用的关系　出处：《中国医药工业杂志》2015年07期 　论文类型：期刊论文

【摘要】：采用体外溶血试验考察,对组成Tween-80的8类化学成分进行致溶血性安全评价。结果显示,它们的致溶血能力有显著差异。聚氧乙烯山梨醇酐(PS)、聚氧乙烯异山梨醇(PI)和聚氧乙烯异山梨醇二油酸酯(PID)在浓度为500?g/ml时未出现溶血,聚氧乙烯山梨醇酐三油酸酯(PSTri)浓度为300?g/ml、聚氧乙烯山梨醇酐四油酸酯(PSTetra)浓度为500?g/ml时可导致溶血,而聚氧乙烯山梨醇酐一油酸酯(PSM)浓度为80?g/ml、聚氧乙烯山梨醇酐二油酸酯(PSD)浓度为120?g/ml、聚氧乙烯异山梨醇一油酸酯(PIM)浓度为30?g/ml时即可导致溶血。提示应控制市售Tween-80中各化学组分的含量,以减少其溶血毒性。
[Abstract]:In vitro hemolysis test was used to evaluate the hemolytic safety of eight kinds of chemical constituents of Tween-80. There were significant differences in their hemolytic ability. The concentrations of PSN, PIand PID50 and PID50 were 500 and 500 respectively, and the results were as follows: (1) the concentration of polyoxyethylene isosorbide dioleate (PID) and polyoxyethylene isosorbide dioleate (PID) were 500? There was no hemolysis at g / ml. The concentration of polyoxyethylene sorbitan trioleate was 300? G / ml, polyoxyethylene sorbitan tetraoleate (PSTetra) = 500? G / ml can lead to hemolysis, while the concentration of polyoxyethylene sorbitan monooleate (PSM) is 80? G / ml, PSDs concentration of polyoxyethylene sorbitan dioleate is 120? G / ml, polyoxyethylene isosorbide monooleate (PIM) concentration is 30? G / ml can lead to hemolysis. It is suggested that the content of each chemical component in Tween-80 should be controlled to reduce its hemolytic toxicity.
【作者单位】：江西中医药大学现代中药制剂教育部重点实验室;江苏省食品药品检验所;
【基金】：国家自然科学基金项目(81160523)
【分类号】：R96
【正文快照】： Tween-80(1)是一种非离子型表面活性剂[1],在药剂中主要作为增溶剂或乳化剂使用。当其作为注射剂药用辅料,特别是应用于静注给药时,存在溶血作用[2,3]。但不同课题组公布的1致溶血性安全评价数据各不相同[4-6]。由于对其化学名的误读以及文献的误导[7],1一直被认为是相对分子

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