异甘草素共晶的热力学研究

发布时间：2018-01-19 08:05

本文关键词： 共晶异甘草素烟酰胺异烟酰胺热力学　出处：《中国新药杂志》2017年18期 　论文类型：期刊论文

【摘要】：目的:探究异甘草素共晶在异丙醇溶剂中的形成热力学。方法:以异甘草素-烟酰胺及异甘草素-异烟酰胺共晶为模型,通过测定303K下异甘草素、烟酰胺及异烟酰胺在异丙醇中的溶解度,计算溶剂中共晶的溶度积和络合常数,并绘制出异甘草素-烟酰胺及异甘草素-异烟酰胺三元相图。结果:2种异甘草素共晶在异丙醇中均符合1∶1溶液络合模型,但2种共晶体系在该条件下的三元相图有较大差异,异甘草素-烟酰胺共晶三相图的共晶区域偏离化学计量比线。常规方法不利于异甘草素共晶的形成。结论:共晶制备方法的优选具有参考意义。
[Abstract]:Objective: to investigate the thermodynamics of isoliberrrhizin eutectic formation in isopropyl alcohol solvent. Methods: isoliquiritisin-nicotinamide and isoglycyrrhizin-isoniacinamide eutectic models were used to determine isoliquiritisin at 303 K. Solubility of nicotinamide and isonicotinamide in isopropyl alcohol, solubility product and complexation constant of eutectic in solvent were calculated. The ternary phase diagrams of isoglycyrrhizin-nicotinamide and isoglycyrrhizin-isoniacinamide were drawn. Results the two isoglycyrrhizin eutectic complexes in isopropanol were in accordance with the 1: 1 solution complexation model. However, the ternary phase diagrams of the two eutectic systems are different under these conditions. The eutectic region of the isoglycyrrhizin-nicotinamide eutectic three-phase diagram deviates from the stoichiometric ratio line. The conventional method is not conducive to the formation of isoliquiritin eutectic. Conclusion: the optimization of eutectic preparation method has reference significance.
【作者单位】：南京中医药大学国家教育部中药炮制规范化及标准化工程研究中心;国家中医药管理局中药炮制标准重点研究室;南京海昌中药集团有限公司江苏省企业研究生工作站;中国药科大学;
【基金】：江苏省自然科学基金(BK20141094) 江苏省中医药局科技项目(PY201518)
【分类号】：R914
【正文快照】： 异甘草素(isoliquiritigenin,ISL)属于甘草中查尔酮类化合物,p Ka为7.50,难溶于水,溶于乙醚、氯仿等极性小的溶剂。具有较强的抗肿瘤、抗病毒、抗炎、抗血管生成等多种生物活性[1-3]。其水中溶解度较差(0.1 mg·m L-1),生物利用度低,大大限制其在临床范围内的应用[4-5]。ISL

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