重组人血小板生成素在不同原发疾病患者中的疗效评价

发布时间：2018-01-23 14:01

本文关键词： 重组人血小板生成素疗效评价血小板计数血液系统疾病重症感染肝移植　出处：《中国医院药学杂志》2017年18期 　论文类型：期刊论文

【摘要】：目的:评价重组人血小板生成素注射液在不同原发病所致血小板减低患者中的疗效。方法:采用回顾性病例对照研究方法,选取某院2013年至2016年使用重组人血小板生成素注射液患者的病例资料,根据血小板减低原因将患者分为血液病组、重症感染组、肝移植组。记录用药前后血小板计数,血小板恢复正常时间,血制品输注量等各项指标。采用SPSS17.0对数据进行统计学方法处理,计数资料采用χ2检验,计量资料采用T检验,评价各组间的疗效。结果:皮下注射重组人血小板生成素注射液各组患者血小板计数明显高于用药前(P0.05),各组间血小板增值比较显示重症感染组与肝移植组血小板增值无显著差异(P0.05),而血液病组血小板计数升高明显低于重症感染组和肝移植组(P0.05);用药后血液病组PLT计数50×109/L持续时间明显高于重症感染组和肝移植组;各组疗效比较血液病组优效比例明显低于重症感染组和肝移植组(P0.05)。3组血小板输注量比较,重症感染组和肝移植组显著低于血液病组(P0.05)。结论:皮下注射常规剂量重组人血小板生成素注射液使患者血小板计数明显上升,恢复加快,血小板输注量明显减少,对重症感染和肝移植患者尤为显著。
[Abstract]:Objective: to evaluate the efficacy of recombinant human thrombopoietin injection in patients with thrombocytopenia caused by different primary diseases. Patients with recombinant human thrombopoietin injection were selected from 2013 to 2016 in a hospital. According to the causes of thrombocytopenia, the patients were divided into hematopathy group and severe infection group. In the liver transplantation group, the platelet count, platelet recovery time and transfusion volume were recorded before and after treatment. The data were processed by SPSS17.0. 蠂 2 test was used for counting data and T test was used for measurement data. Results: the platelet count in subcutaneous injection of recombinant human thrombopoietin injection was significantly higher than that in premedication (P0.05). There was no significant difference in platelet proliferation between severe infection group and liver transplantation group (P 0.05). The platelet count in patients with hematologic diseases was significantly lower than that in patients with severe infection and liver transplantation (P 0.05). The PLT count of 50 脳 10 9 / L in hematologic disease group was significantly longer than that in severe infection group and liver transplantation group. The effective rate of blood disease group was significantly lower than that of severe infection group and liver transplantation group (P 0.05). Conclusion: routine subcutaneous injection of recombinant human thrombopoietin injection can significantly increase platelet count and accelerate recovery in patients with severe infection and liver transplantation. Platelet infusion was significantly reduced, especially in patients with severe infection and liver transplantation.
【作者单位】：天津市第一中心医院药学部;天津市第一中心医院重症医学科;天津医科大学药学院;
【基金】：天津市卫生和计划生育委员会重点课题(编号:2014KR07) 卫生部国家临床重点专科建设项目(编号:2011-873)
【分类号】：R977
【正文快照】： 天津300192;3.天津医科大学药学院应届毕业生)恒定的血小板数目对机体生理病理等过程具有重要意义,如炎症反应、止血、血栓形成、伤口愈合、器官移植排斥等均与血小板的功能、数目密切相关[1]。近年来,各种原发病所致的血小板减少症已成为威胁人类健康的重大疾病之一。各型血

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