口腔膜剂的研究与应用进展

发布时间：2018-01-24 04:20

本文关键词： 口腔膜剂制备评价研究进展　出处：《中国药房》2015年10期 　论文类型：期刊论文

【摘要】：目的:综述口腔膜剂的研究与应用进展,为新剂型的研发提供参考。方法:以"口腔膜剂""口腔速溶膜""Fast dissolving film""Oral strip"或"Oral films"等组合作为关键词,检索1990-2014年中国知网、万方、Springer Link、Pub Med等数据库中的相关文献,对口腔膜剂的特点、分类、组成、包装、质量评价等进行综述。结果与结论:共检索到相关文献113篇,其中有效文献32篇。口腔膜剂常用成膜材料有天然材料、合成材料,其添加剂主要包括增塑剂、甜味剂、稳定剂和增稠剂。随着制备工艺的创新、物理性能评价体系的完善,未来口腔膜剂在纳米给药系统、蛋白给药系统等诸多方面的研究会更加深入,在剂型改进上具有巨大潜力。
[Abstract]:Objective: to review the research and application of oral membrane. Methods: using "oral membrane", "oral instant membrane", "Fast dissolving film" "Oral strip" or "Oral". Combinations such as films "are used as keywords. To search for the relevant documents in the database of China Zhiwang, Wanfang Springer Linker-Pub Med from 1990 to 2014, and to analyze the characteristics, classification, composition and packaging of oral membrane agents. Results and conclusion: a total of 113 literatures were retrieved, of which 32 were effective. There were natural materials and synthetic materials in common use of oral membrane materials. The additives mainly include plasticizer, sweetener, stabilizer and thickener. With the innovation of preparation technology and the improvement of physical performance evaluation system, oral membrane agent will be used in nano-drug delivery system in the future. Many aspects of protein delivery systems will be further studied and have great potential for formulation improvement.
【作者单位】：武警山东总队医院药剂科;
【分类号】：R944.9
【正文快照】： 口服给药方便、无痛苦、患者依从性好,是最常用的给药方式,超过半数的药物制剂是口服给药[1]。常用的口服制剂多为片剂、胶囊、丸剂,均需咀嚼或吞咽进入消化道被吸收后才能起效,给吞咽困难的患者带来了诸多麻烦。尤其是儿童用药,由于其口感、吞咽困难,致使儿童口服药多为液体

【共引文献】