美罗培南致住院患者急性肾损伤的药物不良反应分析

发布时间：2018-01-24 07:16

本文关键词： 美罗培南急性肾损害药物不良反应住院患者　出处：《中国临床药理学杂志》2017年23期 　论文类型：期刊论文

【摘要】：目的研究美罗培南致我院住院患者急性肾损伤的药物不良反应发生情况和相关因素。方法回顾性收集2015年我院住院期间使用美罗培南的400例患者的病历资料,分析用药前后血清肌酸酐水平变化和联合用药情况。通过筛选符合急性肾损伤诊断的病例,并用Naranjo评分法进行美罗培南与急性肾损伤的关联性评价。结果最终共收集到375例患者,其中急性肾损伤组8例(肾损害发生率为2.13%),无急性肾损伤组367例。急性肾损伤组男性6例,年龄(72.83±9.79)岁,女性2例,年龄(84.50±12.02)岁;无急性肾损伤组男性194例,年龄(80.24±11.24)岁,女性173例,年龄(77.84±12.87)岁,2组患者的性别分布和年龄差异均无统计学意义(均P0.05)。应用美罗培南前,急性肾损伤组和无肾损伤组的血清肌酸酐浓度分别为(104.25±53.22)和(100.23±14.54)μmol·L~(-1),差异无统计学意义(P0.05)。应用美罗培南2~11(5.75±2.86)d后,急性肾损伤组血清肌酸酐升高为(304.38±160.78)μmol·L~(-1),与用药前比较,差异有统计学意义(P0.05)。8例急性肾损伤患者中,6例同时联用肾毒性药物,3例出现急性肾损伤后立即改用其他抗菌药。结论美罗培南可导致患者发生急性肾损伤,患者合并易引起肾损害的基础疾病和药物相互作用等可能与急性肾损伤的发生相关。
[Abstract]:Objective to study the incidence of adverse drug reactions and related factors in acute renal injury induced by meropenem in our hospital. Methods 400 patients with meropenem used in our hospital in 2015 were collected retrospectively. Calendar information. The changes of serum creatinine levels before and after treatment and the combined use of drugs were analyzed. The correlation between meropenem and acute renal injury was evaluated with Naranjo score. There were 8 cases in acute renal injury group (the incidence of renal damage was 2.13%, 367 cases in non-acute renal injury group, 6 cases in acute renal injury group, 72.83 卤9.79 years old) and 2 cases in female. The age was 84.50 卤12.02 years old. There were 194 males (80.24 卤11.24) years old and 173 females (77.84 卤12.87) years old in the group without acute renal injury. There was no significant difference in sex distribution and age between the two groups (P 0.05). Serum creatinine concentrations in acute renal injury group and non-renal injury group were 104.25 卤53.22 and 100.23 卤14.54 渭 mol 路L ~ (-1), respectively. The difference was not statistically significant (P 0.05). After using meropenem 211115.75 卤2.86 days later. Serum creatinine was increased to 304.38 卤160.78 渭 mol 路L ~ (-1) mol 路L ~ (-1) in acute renal injury group. The difference was statistically significant in 6 of the 8 patients with acute renal injury who were treated with nephrotoxic drugs at the same time. Three patients with acute renal injury were treated with other antibiotics immediately. Conclusion meropenem can lead to acute renal injury. The underlying diseases and drug interactions may be associated with acute renal injury.
【作者单位】：首都医科大学附属北京世纪坛医院药剂科;北京大学药学院药事管理与临床药学系;首都医科大学化学生物学与药学院临床药学系;
【分类号】：R978.1
【正文快照】： (1.首都医科大学附属北京世纪坛医院药剂科,北京100038;2.北京大学药学院药事管理与临床药学系,北京100191;3.首都医科大学化学生物学与药学院临床药学系,北京100069)DU Zhao-yang1,2,XIE Zheng-zheng1,ZHAO Ying1,2,CHEN Zhang-yong1,3,LI Guang-yao1,2,SUN Lu-lu1(1.Departm

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