抗感染药物相关严重不良反应147例分析

发布时间：2018-01-24 21:19

本文关键词： 严重不良反应抗感染药物合理用药　出处：《中国临床药理学杂志》2017年01期 　论文类型：期刊论文

【摘要】：目的分析抗感染药物相关严重不良反应发生的特点及规律并提出防范措施。方法将本院药剂科不良反应监测员收到的2010至2014年各临床科室上报的不良反应报告中,怀疑药品为抗感染药物,且为严重不良反应的报告纳入,将关联性评价为"可能无关"或"待评价"或"无法评价"的报告剔除。对最终纳入研究的147例抗感染药物相关严重不良反应报告进行分析。结果 147例严重不良反应中,共涉及抗感染药物13类,24个品种。居前3位的分别为利奈唑胺114例(77.5%)、左氧氟沙星4例(2.72%)、阿莫西林3例(2.04%)。严重不良反应的临床表现以血液系统损害最多,为112例(76.19%);其次为肝胆系统损害14例(9.52%)及皮肤及其附件损害10例(6.80%)。结论要加强医务人员对于抗感染药物相关不良反应的重视,提高合理用药水平。
[Abstract]:Objective to analyze the characteristics and regularity of severe adverse reactions associated with anti-infective drugs and to put forward preventive measures. Methods the adverse reactions monitors received by the pharmacists of our hospital from 2010 to 2014 were not reported to the clinical departments. In the good reaction report. Suspected drugs were anti-infective drugs and were included in reports of severe adverse reactions. The results of the analysis of 147 cases of severe adverse reactions related to anti-infective drugs that were ultimately included in the study were taken out of the report of relevance evaluation as "possible irrelevant" or "to be evaluated" or "unable to evaluate". 147 cases of severe adverse reactions. There were 13 classes and 24 varieties of anti-infective drugs. Among them, the top 3 were alanazolamide (114 cases) and levofloxacin (4 cases (2.722)). The clinical manifestations of severe adverse reactions were as follows: blood system damage was the most common, 112 cases were 76.19 cases; Secondly, there were 14 cases of hepatobiliary system damage (9.52%) and 10 cases of skin and its adnexal damage (6.80%). Conclusion Medical staff should pay more attention to adverse reactions related to anti-infective drugs. Improve the level of rational use of drugs.
【作者单位】：北京大学第一医院药剂科;
【分类号】：R978
【正文快照】： 与抗感染药物相关的药物不良反应(adverse drug reaction, ADR)是抗感染治疗过程中必须面对的问题。近年来,除了滥用抗菌药物及超级耐药菌的产生问题之外,抗感染药物相关的ADR也越来越被临床所重视[1]。特别是严重ADR(serious AD,SADR),是除了治疗效果之外,与患者预后情况密

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