2012～2014年我院抗肿瘤药物超说明书用药调查分析与合理性评价

发布时间：2018-01-25 22:30

本文关键词： 抗肿瘤药物超说明书用药合理用药　出处：《中国医药导报》2016年08期 　论文类型：期刊论文

【摘要】：目的了解新疆医科大学附属肿瘤医院(以下简称"我院")抗肿瘤药超说明书用药情况,探讨抗肿瘤药物应用合理性评价方法。方法随机抽取我院2012~2014年应用抗肿瘤药物医嘱的成年人出院病历,根据药品说明书,分析超说明书用药情况。结合美国国立综合癌症网络(NCCN)相关恶性肿瘤临床实践指南,对超说明书用药进行合理性评价。结果共抽取3600份病历,含8895条抗肿瘤药医嘱。其中,超说明书用药医嘱2868条,占32.24%。超说明书用药发生率较高的抗肿瘤药依次为抗肿瘤抗生素(48.72%)、其他抗肿瘤药物(36.33%)及烷化剂(30.99%);超说明书用药类型前3位的是超适应证(44.98%)、超溶媒用量(38.91%)及溶媒品种(7.53%)。参照NCCN指南进行合理性评价,其中65.48%超说明书用药不合理,不合理的情况主要为溶媒用量、溶媒品种、给药途径。结论我院抗肿瘤药超说明书使用普遍存在,部分超说明书使用有一定的合理性。医院应完善医嘱系统,规范护理操作,临床药师积极参与并干预抗肿瘤药物的应用,以确保化疗患者用药的安全有效,优化治疗方案。
[Abstract]:Objective to investigate the drug usage of antitumor drugs in the Cancer Hospital affiliated to Xinjiang Medical University (hereinafter referred to as "our hospital"). Methods the medical records of adults who were ordered to use antitumor drugs in our hospital from 2012 to 2014 were randomly selected according to the drug instructions. According to the clinical practice guide of NCCN-related malignant tumor in the United States, the reasonableness of drug use was evaluated. Results A total of 3600 medical records were extracted. Contains 8895 antitumor drug orders. Among them, 2868 prescriptions exceed instructions. The antitumor agents with higher incidence rate were 48.72 antineoplastic antibiotics and 36.333.33% other antitumor drugs) and alkylating agents 30.99%. The first three types of superprescriptions were superindications (44.98%), supersolute dosage (38.91) and solute variety (7.53%). The rationality was evaluated with reference to the NCCN guidelines. Among them, 65.48% superscript is unreasonable, the main unreasonable situation is the dosage of solvent, the variety of solute and the way of administration. Conclusion the use of superspecification of anti-tumor drugs in our hospital is widespread. The hospital should perfect the system of doctor's advice, standardize the nursing operation, and the clinical pharmacist take an active part in and intervene in the application of antitumor drugs to ensure the safety and effectiveness of chemotherapy patients. Optimize the treatment plan.
【作者单位】：新疆医科大学附属肿瘤医院药学部;
【基金】：新疆医科大学附属肿瘤医院科研启动基金项目(肿2014-08)
【分类号】：R95
【正文快照】： 药品说明书是经国家药品监督管理部门批准、药品生产企业提供、用以指导安全合理使用药品的技术性资料和法定文件,包含药品有效性和安全性等重要科学数据和信息[1]。美国医疗机构药师协会将超说明书用药定义为:药品使用的适应证、给药途径、剂量或适应人群不在美国食品药品管

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