姜黄素固体脂质纳米粒在大鼠体内的药动学

发布时间：2018-01-31 16:05

  本文关键词： 姜黄素 固体脂质纳米粒 口服药动学　出处：《中国医院药学杂志》2015年04期 　论文类型：期刊论文

【摘要】：目的:研究姜黄素固体脂质纳米粒在SD大鼠体内的口服药动学情况。方法:大鼠单剂量灌胃给予姜黄素固体脂质纳米粒和游离药姜黄素,眼底静脉丛取血,以醋酸乙酯处理血浆样品,尼群地平为内标,高效液相法(HPLC)测定血浆中姜黄素的含量,并用药物与统计(Drug and Statistics,DAS)软件分析处理药动学数据。结果:姜黄素固体脂质纳米粒和游离药姜黄素在大鼠体内的药动学行为均符合二室开放模型,姜黄素固体脂质纳米粒和游离药姜黄素的药动学参数分别如下:药时曲线下面积(AUC0-t)为(798.00±64.44)μg·h·L-1和(108.78±14.22)μg·h·L-1,药时曲线下总面积(AUC0-∞)为(939.49±114.18)μg·h·L-1和(126.99±28.14)μg·h·L-1,峰浓度(Cmax)为(93.84±5.66)μg·L-1和(72.46±2.66)μg·L-1,消除半衰期(t1/2)为(17.16±1.61)h和(4.71±1.18)h,姜黄素固体脂质纳米粒的AUC0-t、AUC0-∞、Cmax和t1/2分别提高了7.34,7.40,1.30和3.64倍。结论:姜黄素固体脂质纳米粒体内消除慢,血药浓度高,且明显提高了姜黄素的口服生物利用度。
[Abstract]:Objective: to study the pharmacokinetics of curcumin solid lipid nanoparticles in SD rats. Methods: rats were given curcumin solid lipid nanoparticles and free curcumin respectively. The plasma samples were treated with ethyl acetate and nitrendipine was used as internal standard. The content of curcumin in plasma was determined by high performance liquid chromatography (HPLC). Drugs and statistics were used for drug and Statistics. Results: the pharmacokinetic behavior of curcumin solid lipid nanoparticles and free curcumin in rats was in accordance with the two-compartment open model. The pharmacokinetic parameters of curcumin solid lipid nanoparticles and curcumin were as follows: the area under the drug time curve (AUC0-t) was 798.00 卤64.44 渭 g 路h 路L -1 and (. 108.78 卤14.22 渭 g 路h 路L -1. The total area under the drug time curve was 939.49 卤114.18 渭 g 路h 路L -1 and 126.99 卤28.14 渭 g 路h 路L -1 respectively. The peak concentration of C _ (max) was 93.84 卤5.66 渭 g 路L ~ (-1) and 72.46 卤2.66 渭 g 路L ~ (-1). The elimination half-life was 17.16 卤1.61h and 4.71 卤1.18hrespectively, and the AUC0-tU AUC0- 鈭，

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