二甲双胍对奥氮平灌胃大鼠胰岛素抵抗的改善作用

发布时间：2018-02-03 16:52

本文关键词： 奥氮平二甲双胍胰岛素抵抗糖耐量　出处：《上海交通大学学报(医学版)》2017年08期 　论文类型：期刊论文

【摘要】：目的·探讨二甲双胍对奥氮平灌胃大鼠胰岛素抵抗相关代谢参数的改善作用。方法·将30只雌性SD大鼠随机分为二甲双胍干预组、奥氮平组和生理盐水对照组。第1~6周,前2组给5 mg/(kg·d)奥氮平、第3组给等量生理盐水进行灌胃。第7周开始,干预组合用二甲双胍500 mg/(kg·d),奥氮平组合用等量生理盐水,继续灌胃4周。6周末及10周末评估腹腔葡萄糖耐量和胰岛素抵抗指数。结果·6周末,干预组及奥氮平组腹腔葡萄糖耐量曲线下面积(P=0.040)、胰岛素抵抗指数(P=0.000)显著高于对照组。10周末时,干预组糖耐量(P=0.015)及胰岛素抵抗指数明显低于奥氮平组(P=0.001)。结论·二甲双胍治疗可以纠正奥氮平引起的糖耐量受损,部分改善胰岛素抵抗。
[Abstract]:Objective: to investigate the effect of metformin on insulin resistance related metabolic parameters in rats fed with olanzapine. Methods: 30 female SD rats were randomly divided into metformin intervention group. Olanzapine group and saline control group. The first two groups were given 5 mg/(kg 路d) olanzapine at the 1st week, and the third group was given the same amount of saline by stomach. The intervention group was treated with metformin 500 mg/(kg 路dl and olanzapine with the same amount of normal saline. The glucose tolerance and insulin resistance index were evaluated at the end of 4 weeks and 10 weeks. Results at the end of 6 weeks, the area under the glucose tolerance curve of the intervention group and olanzapine group was 0.040). The insulin resistance index was significantly higher than that of the control group at the end of 10 weeks. The glucose tolerance and insulin resistance index in the intervention group were significantly lower than those in the olanzapine group. Conclusion Metformin therapy can correct the impaired glucose tolerance caused by olanzapine. Partially improve insulin resistance.
【作者单位】：上海交通大学医学院附属精神卫生中心;上海市重性精神病重点实验室;
【基金】：上海市科学技术委员会科研计划项目(13ZR1435800) 上海交通大学医学院转化医学协同创新中心课题(TM201506)~~
【分类号】：R965
【正文快照】： 非典型抗精神病药物由于其强效抗精神病作用、较少锥体外系不良反应而成为临床上精神分裂症治疗的一线用药,然而它们却极易引起以胰岛素抵抗(insulin resistance,IR)为核心的代谢综合征[1],尤其是奥氮平。尽管有研究表明奥氮平在控制患者精神病性症状、降低再入院率方面优势明

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