含羟乙基淀粉类药品致不良反应43例文献分析

发布时间：2018-02-04 04:08

本文关键词： 羟乙基淀粉药品不良反应文献分析　出处：《中国药房》2015年08期 　论文类型：期刊论文

【摘要】：目的:探讨含羟乙基淀粉类药品致不良反应(ADR)发生的一般规律及特点,为临床安全、合理用药提供参考。方法:以"羟乙基淀粉""706代血浆"作为关键词检索到中国知网(CNKI)、中文科技期刊数据库(VIP)、万方数据库1994-2014年收录的含羟乙基淀粉类药品致ADR的相关文献34篇,共43例,对纳入文献ADR患者的年龄、性别、原发疾病、引发药品及给药途径、联合用药情况、ADR出现时间、累及器官/系统以及临床表现、转归、ADR类型、死亡病例等进行统计和分析。结果:发生ADR患者的男、女比例为2.07∶1,以≥60岁老年患者居多,占41.86%;原发疾病以心脑血管系统疾病为主,占68.89%;ADR临床表现主要为心血管系统损害(36.67%)、呼吸系统损害(14.07%)、皮肤及其附件损害(13.70%);ADR发生的时间集中在用药30 min内(44.19%);死亡6例。结论:临床应重视含羟乙基淀粉类药品致ADR的分布规律,对高发生率ADR和高风险患者应重点监护,以确保用药安全。
[Abstract]:Objective: To investigate the effect of hydroxyethyl starch containing drug induced adverse reactions (ADR) rules and characteristics, to provide reference for clinical safe and rational drug use. Methods: "hydroxyethyl starch" and "706 generation plasma" as the keyword search to China HowNet (CNKI), Chinese scientific journal database (VIP), Wanfang database 1994-2014 collected related literature by ADR hydroxyethyl starch containing drugs 34, a total of 43 cases of ADR patients in the literature of gender, age, primary disease, caused by drug and route of administration, drug combination, ADR occurs, involving organs / systems and clinical manifestations, prognosis, ADR type of statistics and analysis of death cases. Results: the ADR patients were male, female ratio of 2.07 to 1, with the majority of elderly patients aged over 60, accounting for 41.86%; the primary diseases in cardiovascular system disease, accounted for 68.89%; ADR was the main clinical manifestation of cardiovascular system damage ( 36.67%), respiratory system damage (14.07%), the damage of skin and its appendages (13.70%); the time of occurrence of ADR concentration in 30 min after administration (44.19%); 6 cases died. Conclusion: clinical attention should be paid to the distribution of drug induced ADR with hydroxyethyl starch, the high incidence of ADR and high risk patients should focus on care, to ensure drug safety.

【作者单位】：甘肃省人民医院;
【分类号】：R973
【正文快照】： 羟乙基淀粉(Hydroxythyl starch,HES)于20世纪70年代问世,是以糯玉米淀粉为原料,经轻度酸水解,并在碱性条件下以环氧乙烷(或者2-氯乙醇)进行羟基化而制成[1]。羟乙基淀粉为一种主要用于治疗和预防血容量不足的血容量扩张药,临床上还用于急性等容性血液稀释、各种休克和有效循

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