氧氟沙星胃漂浮微丸的制备

发布时间：2018-02-04 18:55

本文关键词： 氧氟沙星胃漂浮微丸星点设计效应面优化法　出处：《沈阳药科大学学报》2015年09期 　论文类型：期刊论文

【摘要】：目的制备以氧氟沙星为主药的胃漂浮缓释微丸。方法以微晶纤维素为骨架材料,采用挤出滚圆法制备氧氟沙星微丸。以Kollicoat SR30D为内层包衣材料(缓释层),碳酸氢钠为中间层(产气层),Eudragit RL30D为外层包衣材料(阻滞层)进行包衣,制成氧氟沙星胃漂浮微丸。通过星点设计-效应面优化法考察了胃漂浮微丸的处方,分别考察各处方微丸的漂浮性和体外释放性质。结果试验制得的胃漂浮微丸既能快速起漂、持续漂浮达8 h以上,又能达到2、4、8和24 h累计释放率分别为(32.37±0.88)%、(50.18±0.37)%、(69.36±0.89)%和(97.64±0.87)%的缓释效果。结论所制得的包衣微丸在人工胃液(p H=1.2)中具有良好的漂浮性能和缓释性能。
[Abstract]:Objective to prepare gastric floating sustained-release pellets with ofloxacin as the main drug. Methods Microcrystalline cellulose was used as skeleton material. Ofloxacin pellets were prepared by extrusion round method. Kollicoat SR30D was used as inner coating material (slow release layer) and sodium bicarbonate as intermediate layer (gas producing layer). Eudragit RL30D coated the outer coating material (block layer) to make ofloxacin floating pellets. The formulation of the pellets was investigated by star design-effect surface optimization method. The floating properties and in vitro release properties of each prescription pellets were investigated respectively. Results the gastric floating pellets could be floated rapidly for more than 8 hours and up to 2? The cumulative release rates at 8 h and 24 h were 32.37 卤0.88% and 50.18 卤0.37%, respectively. 69.36 卤0.89% and 97.64 卤0.87% respectively. Conclusion the coated pellets were prepared in artificial gastric juice. It has good floating performance and slow release property.
【作者单位】：沈阳药科大学药学院;
【基金】：辽宁大学“大学生创新训练计划”资助项目(201310163010)
【分类号】：R943
【正文快照】： 氧氟沙星(oflxoacin,OFLX)是一广谱抗菌药[1-2],在酸中溶解度好,在中性和碱性肠液中溶解度低,口服易吸收,吸收部位主要在十二指肠和空肠,其吸收速率和程度依赖于胃肠道的p H、溶出速率、胃排空速率。适合制备胃滞留制剂的药物类型:在胃部具有活性的药物及一些抗幽门螺旋杆菌的

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