基于新型交联剂Eudragit RS100的凝胶贴膏基质考察

发布时间：2018-02-12 20:21

本文关键词： 凝胶贴膏制川乌白芍 Eudragit RS 交联剂基质透皮　出处：《中国医药工业杂志》2015年12期 　论文类型：期刊论文

【摘要】：测定并对比了以Eudragit RS100或氯化铝为交联剂时聚丙烯酸钠(PAA-Na)溶液的屈服值与黏度,结果二者无显著差异。但根据绘制的流变曲线可见,以Eudragit RS100为交联剂的体系黏度较均一,有利于提高凝胶基质中药物含量的均匀性。在此基础上加入羧甲纤维素钠(CMC-Na)为增黏剂,制备空白凝胶贴膏基质,并用Box-Behnken设计-效应面法优化基质处方。所得优化处方为含PAA-Na、Eudragit RS100和CMC-Na各4.0%、0.2%和14.0%。以制川乌和白芍的提取物为模型药物制备了以Eudragit RS100或氯化铝为交联剂的乌芍凝胶贴膏,并考察了两种制品中芍药苷的透皮行为。结果两种制品中芍药苷的稳态透皮速率和释放时滞均无显著差异,提示以Eudragit RS100为交联剂并不影响该凝胶贴膏中药物的经皮渗透性能。
[Abstract]:The yield value and viscosity of sodium polyacrylate (PAA-Na) solution with Eudragit RS100 or aluminum chloride as crosslinker were measured and compared. The results showed that there was no significant difference between them. However, according to the rheological curves drawn, the viscosity of the system with Eudragit RS100 as crosslinking agent was uniform. It is helpful to improve the homogeneity of the drug content in gel matrix, on the basis of which CMC-Na is added as viscosity enhancer to prepare blank gel paste matrix. The matrix formulation was optimized by Box-Behnken design-effect surface method. The optimized formulation was 0.2% and 14.0%, respectively, containing PAA-NaA- Eudragit RS100 and CMC-Na. The extract of Radix Paeoniae lanceolata and Radix Paeoniae Alba was used as model drug to prepare the gel paste of Radix Paeoniae AlCl or Eudragit RS100 as crosslinking agent. The transdermal behavior of paeoniflorin in the two kinds of products was also investigated. Results there was no significant difference in the steady-state transdermal rate and release delay of paeoniflorin between the two kinds of products, suggesting that the transdermal permeability of paeoniflorin in the gel paste was not affected by Eudragit RS100 as crosslinking agent.
【作者单位】：江西中医药大学;
【基金】：国家自然科学基金项目(81360647) 江西省高等学校大学生创新创业计划项目(201310412032)
【分类号】：R943

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