基于压缩性质研究羟丙甲纤维素粒径对硝苯地平缓释片释放度的影响

发布时间：2018-02-14 21:09

本文关键词： 羟丙甲纤维素压缩性质粒径硝苯地平缓释片释放度　出处：《中国药学杂志》2017年06期 　论文类型：期刊论文

【摘要】：目的基于羟丙甲纤维素(HPMC)的压缩性质,研究HPMC粒径对硝苯地平亲水凝胶骨架缓释片释放度影响的机制。方法测定不同粒径HPMC K4M的压缩性质,以硝苯地平为模型药物,HPMC K4M为骨架材料,制备亲水凝胶骨架缓释片。研究HPMC K4M的压缩性质对缓释片孔隙率、释放度等性质的影响。结果随着粒径的减小,HPMC K4M的堆密度、振实密度、压缩度、抗张强度逐渐增大,弹性恢复逐渐减小,使得硝苯地平缓释片的厚度和孔隙率逐渐减小,单位体积HPMC浓度逐渐增大,导致HPMC凝胶速率加快,使得水分渗入骨架片速率减慢,骨架膨胀减慢,释放度减小。结论不同粒径分布HPMC的压缩性质明显不同,从而显著影响硝苯地平缓释片的孔隙率和凝胶骨架的形成速率,进而影响缓释片的释放度。
[Abstract]:Objective to study the mechanism of the effect of HPMC particle size on the release of nifedipine hydrophilic gel matrix sustained-release tablets based on the compression properties of HPMC. Methods the compression properties of HPMC K4M with different diameters were determined. The hydrophilic gel matrix sustained-release tablets were prepared with nifedipine as the model drug HPMC K4M. The effects of compression properties of HPMC K4M on the porosity and release of HPMC K4M were studied. Results the bulk density of HPMC K4M decreased with the particle size of HPMC K4M. The density, compression, tensile strength and elastic recovery of nifedipine sustained-release tablets gradually increased, and the thickness and porosity of nifedipine sustained release tablets gradually decreased, and the HPMC concentration per unit volume gradually increased, which led to the acceleration of HPMC gel rate. The results showed that the rate of water permeation into the matrix decreased, the expansion of the matrix decreased and the release rate decreased. Conclusion the compression properties of HPMC with different particle size distributions are obviously different, which has a significant effect on the porosity of nifedipine sustained-release tablets and the formation rate of gel skeleton. Furthermore, the release of sustained release tablets was affected.
【作者单位】：华东理工大学药学院;杭州民生药业有限公司;
【分类号】：R943

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