非洛地平和磷酸奥司他韦中相关杂质的合成

发布时间：2018-02-16 19:32

本文关键词： 杂质非洛地平磷酸奥司他韦　出处：《南方农机》2015年04期 　论文类型：期刊论文

【摘要】：目的:分析非洛地平和磷酸奥司他韦中相关杂质的合成效果。方法:分别合成非洛地平中杂质A2,6-二甲基-4-(2,3-二氯苯基)-3,5-吡啶二甲酸乙酯、B2,6-二甲基-4-(2,3-二氯苯基)-1,4-二氢-3,5-吡啶二甲酸二甲酯、C2,6-二甲基-4-(2,3-二氯苯基)-1,4-二氢-3,5-吡啶二甲酸二乙酯,磷酸奥司他韦中杂质D3R,4R,5S)-3-(1-乙基丙氧基)-4-乙酰胺-5-氨基-1-环己烯-1-羧酸、E3-羟基-4-乙酰氨基苯甲酸乙酯。结果:获得杂质A(白色固体1.57g),收率78.2%,含量98.5%,杂质B(类白色固体19.10g),收率89.60%,杂质C(12.00g),收率86.10%,杂质D(白色固体0.61g),收率88.04%,杂质E(白色固体0.36g),收率86.69%,氢谱数据检测为高纯度杂质。结论:非洛地平和磷酸奥司他韦中相关杂质合成技术已基本成熟,合成效果较好,可在实验室合成制备,作为非洛地平和磷酸奥司他韦质量检测对照品。
[Abstract]:Objective: to analyze the synthetic effect of related impurities in felodipine and oseltamivir phosphate. Methods: the impurities A _ 2o _ 6- dimethyl -4-dimethylidene _ 3-dichlorobenzyl _ 3-dichlorobenzyl _ 5-pyridine _ ethyl ester _ (B _ 2o _ 6-dimethyl -4-dimethylidene _ 2o _ 3-dichlorophenyl -1o _ 4H _ 2H _ 2) in felodipine were synthesized respectively. Dimethyl pyridine-6-dimethyl-6-dimethyl-4-trichlorobenzene-3-dichlorobenzyl-4-diethyl diethyl dihydro-3-pyridine-5-pyridyl dicarboxylic acid, dimethyl pyridine dimethyl dimethyl dimethyl ester, dimethyl pyridine dimethyl dicarboxylate. The impurity in oseltamivir phosphate, D _ 3R _ (4) R _ (4) R _ (5) S _ (5) O _ (3) H _ (2) O _ (2) O _ (2) H _ (2) O _ (3) H _ (3) -4-acetyl benzoate ethyl ester. Results: the impurity A (white solid 1.57 g) was obtained in 78.2 yield, 98.5%, impurity B (similar to white solid). 19.10 g / g, yield 89.60%, impurity C _ (12) 0.00 g ~ (-1), yield 86.10%, impurity D (white solid 0.61 g ~ (-1)), yield 88.04, impurity E (white solid 0.36 g ~ (-1), yield = 86.69), hydrogen spectrum data detected as high purity impurity. Conclusion: the synthesis technology of related impurities in felodipine and oseltamivir phosphate is basically mature, It can be prepared in laboratory and be used as a reference substance for the quality determination of Felodipine and oseltamivir phosphate.
【作者单位】：江苏连云港润众制药有限公司;
【分类号】：R914.5

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