红芸豆植物凝集素长期阴道给药对小鼠阴道上皮细胞的影响
发布时间:2018-02-23 02:56
本文关键词: 红芸豆 植物凝集素 杀微生物剂 小鼠 阴道上皮细胞 切片 出处:《中国计划生育学杂志》2016年11期 论文类型:期刊论文
【摘要】:目的:观察长期阴道使用红芸豆植物凝集素(RKBL)对小鼠阴道上皮细胞的影响。方法:使用不同浓度的RKBL注入小鼠阴道连续给药4个月后断颈处死小鼠,取其阴道及周围组织,制作石蜡切片并经苏木精染色,显微镜下观察阴道组织的形态学变化。结果:小鼠阴道在浓度≤2.5mg/只的RKBL处理后,无炎症病变,阴道粘膜上皮细胞形态完好无破损,皮下组织形态正常。而当给药浓度提高到5mg/只时,阴道黏膜浅层上皮细胞出现空泡化。结论:浓度≤2.5mg/只的RKBL长期使用不会引起阴道黏膜上皮细胞及皮下组织的不良反应。
[Abstract]:Objective: to observe the effect of long-term vaginal administration of RKBLs on the vaginal epithelial cells of mice. Methods: the mice were sacrificed by vaginal administration of different concentrations of RKBL for 4 months, and their vagina and surrounding tissues were taken. The morphological changes of vagina tissue were observed under microscope. Results: after treated with RKBL with concentration 鈮,
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