枸橼酸坦度螺酮对自发性高血压大鼠血压的影响及机制研究

发布时间：2018-02-27 05:25

  本文关键词： 枸橼酸坦度螺酮 自发性高血压大鼠 内皮功能　出处：《中国药房》2017年22期 　论文类型：期刊论文

【摘要】：目的:研究枸橼酸坦度螺酮(TC)对自发性高血压大鼠(SHR)血压的影响及机制。方法:将SHR随机分为模型组、阳性对照组(苯磺酸左旋氨氯地平片,2.5 mg/kg)和TC高、中、低剂量组(TC胶囊,40、20、10 mg/kg),每组8只,另设8只正常大鼠为正常对照组,每天ig药物1次,连续28 d。测量各组大鼠首次给药前及给药后0.5、1、1.5、2、3、4 h的收缩压(SBP),另每给药7 d测量1次1 h的SBP;末次给药后检测血清中一氧化氮(NO)含量,血浆中内皮素、肾素、血管紧张素Ⅱ(AngⅡ)和去甲肾上腺素(NE)含量。结果:单次给药时,与模型组比较,阳性对照组和TC各剂量组SHR首次给药后0.5、1 h时的SBP均明显降低(P0.05或P0.01),之后仅阳性对照组和TC高剂量组的SBP明显降低(P0.05或P0.01);多次给药时,与模型组比较,阳性对照组和TC高、中剂量组SHR给药第7、14、28天的SBP均明显降低(P0.05或P0.01)。与模型组比较,阳性对照组和TC高剂量组SHR血清中NO含量明显升高,血浆中内皮素、肾素、AngⅡ和NE含量均明显降低(P0.05或P0.01);与阳性对照组比较,TC各剂量组SHR血清中NO含量明显降低,TC中剂量组SHR血浆中内皮素含量明显升高(P0.05)。结论:TC可明显降低SHR血压,其机制可能与调节NO和内皮素释放平衡,降低肾素、AngⅡ及NE含量有关。
[Abstract]:Objective: to study the effect and mechanism of tandoxone citrate on blood pressure in spontaneously hypertensive rats. Methods: SHR was randomly divided into model group, positive control group (L-amlodipine benzenesulfonic acid 2.5 mg / kg) and high TC. In the low dose group, there were 8 rats in each group, 8 rats in each group, and 8 normal rats as control group. For 28 consecutive days, systolic blood pressure (SBP) was measured before and after the first administration of the drug, and the systolic blood pressure (SBP) was measured for 4 hours before and after the first administration of the drug, and 1 hour for every 7 days. The contents of nitric oxide (no) in serum, endothelin (et) and renin (renin) in plasma were measured after the last administration. Results: compared with the model group, the contents of angiotensin 鈪，

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