药物作用量—效关系重心有理插值法的研究

发布时间：2018-03-03 11:30

本文选题：田螺多糖　切入点：阿可拉定　出处：《山西医科大学学报》2016年12期 　论文类型：期刊论文

【摘要】：目的研究并建立新的药物量效关系分析方法。方法以田螺多糖(PCC)、阿可拉定(icartin)抑制癌细胞增殖的量效关系为例,提出保形重心有理插值法。根据插值条件,求出药物量效关系表达式,计算药物半数抑制浓度IC50;求导表达式,研究抑制率随药物浓度变化的快慢程度。结果根据得到量效关系函数表达式计算出PCC与icartin的IC50分别为315.86mg/L和9.24μmol/L;导数图表明PCC浓度在100 mg/L内(icartin浓度在10μmol/L内),抑制率随浓度变化速度快,药物作用不稳定;PCC浓度大于700 mg/L(icartin浓度大于40μmol/L),抑制率变化不明显,药效稳定。结论保形重心有理插值法运算简单,准确性高,是一种新的药物量效关系分析方法。
[Abstract]:Objective to study and establish a new dose-effect relationship analysis method. Methods taking the dose-effect relationship of PCCX and acoladine in inhibiting the proliferation of cancer cells as an example, a conformal barycenter rational interpolation method was proposed. The expression of dose-effect relationship was obtained, and the IC50 of drug half inhibitory concentration was calculated. Results the IC50 of PCC and icartin were calculated to be 315.86 mg / L and 9.24 渭 mol / L, respectively, and the derivative diagram showed that the concentration of PCC was within 10 渭 mol/L and the inhibition rate was as follows: the concentration of PCC was within 10 渭 mol/L. The concentration changes quickly. When the concentration of PCC was greater than 700 渭 mol / L, the inhibition rate was not obvious and the drug effect was stable. Conclusion the rational interpolation method of conformal barycenter is simple and accurate, and it is a new method for the analysis of dose-effect relationship.
【作者单位】：安徽理工大学医学院药理教研室;安徽理工大学理学院数学教研室;
【基金】：国家自然科学基金资助项目(60973050) 安徽省教育厅高校省级自然科学重点研究项目(KJ2008A014) 安徽理工大学青年教师科研基金项目(QN201146)
【分类号】：R96

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