氨甲环酸对膝关节置换术后血红蛋白降低的临床研究

发布时间：2018-03-04 07:04

本文选题：氨甲环酸　切入点：剂量　出处：《中国临床药理学杂志》2015年13期 　论文类型：期刊论文

【摘要】：目的评价不同剂量氨甲环酸对膝关节置换术后血红蛋白降低的影响。方法 116例膝关节置换术患者随机分为试验组58例与对照组58例。2组患者的手术流程与方法一样,对照组在切皮前经静脉注射氨甲环酸50 mg·kg-1,试验组静脉注射氨甲环酸100 mg·kg-1,观察2组围手术指标(手术时间、切口长度、术中出血量、术后引流量、总输血量),血红蛋白变化和凝血四项指标。结果 2组患者均顺利完成手术出院。试验组的术中出血量、术后引流量、总输血量明显少于对照组(P0.05)。2组术后血红蛋白含量都呈明显降低趋势(P0.05),试验组术后的血红蛋白含量明显高于对照组(P0.05)。2组间术前与术后的凝血四项指标差异无统计学意义(P0.05)。术后随访3个月,试验组出现深静脉血栓(1例),急性心肌梗死(0例),一过性神经症状(1例)等并发症发生率明显低于对照组(5,3,4例)(P0.05)。结论大剂量氨甲环酸的应用能够减少膝关节置换术术中出血量与输血量,缓解术后血红蛋白的降低,对凝血功能无影响,安全性更好。
[Abstract]:Objective to evaluate the effect of different doses of carbamoic acid on hemoglobin reduction after knee arthroplasty. Methods 116 patients with knee arthroplasty were randomly divided into experimental group (n = 58) and control group (n = 58). In the control group, 50 mg 路kg -1 of methocylic acid was injected intravenously before skin incision, and 100 mg 路kg -1 of methocylic acid was injected intravenously in the experimental group. The perioperative indexes (operative time, incision length, intraoperative bleeding volume and postoperative drainage volume) were observed in the two groups. Results the patients in both groups were discharged successfully. The total blood transfusion volume was obviously lower than that of the control group P0.05n.2 group. The hemoglobin content in the experimental group was significantly lower than that in the control group P0.050.2.There was no significant difference in the four indexes of coagulation before and after operation between the control group and the control group. All patients were followed up for 3 months. The incidence of complications such as deep venous thrombosis in 1 case, acute myocardial infarction in 0 cases and transient neurological symptoms in 1 case in the trial group were significantly lower than those in the control group (P 0.05). Conclusion the application of high dose of carbamoic acid can reduce the replacement of knee joint. Blood loss and blood transfusion during operation, The reduction of hemoglobin after operation was alleviated, the coagulation function was not affected, and the safety was better.
【作者单位】：承德医学院附属医院骨外三科;承德医学院附属医院承钢分院骨科;河北省宽城满族自治县县医院内窥镜室;
【基金】：承德市科学技术研究与发展计划基金资助项目(20142060)
【分类号】：R969

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