药物消除半衰期测定方法的误区与纠正

发布时间：2018-03-05 02:23

本文选题：药物消除　切入点：半衰期　出处：《医学争鸣》2015年06期 　论文类型：期刊论文

【摘要】：药物消除半衰期是最常使用和最重要的药物代谢动力学参数,一般采用单次静脉注射后不同时间采血的方法测定。该法由于药物分布的参与,存在药物分布完成的时间难以确定,过多的失血影响消除,单次给药的血药浓度可能低于临床实际,消除相血药浓度低而误差大,使测定的半衰期结果与实际可能会有较大距离。我们推荐一种基于单纯消除的药物半衰期测定方法,采用长时间(至少5个半衰期)持续静脉滴注,使给药速度等于体内药物的消除速度,其分布到达平衡后,再停止给药。此时血药浓度的变化仅反映药物的消除,于不同时间静脉采血,再计算药物的消除半衰期,这样的结果更接近体内药物消除的实际状况。
[Abstract]:Drug elimination half-life is the most commonly used and most important pharmacokinetic parameter. It is usually determined by blood collection at different times after a single intravenous injection. The time of completion of drug distribution is difficult to determine, too much blood loss can be eliminated, the blood drug concentration of single dose may be lower than that of clinical practice, and the elimination phase of blood drug concentration is low and the error is large. We recommend a drug half-life determination method based on simple elimination for a long (at least 5 half-life) duration of intravenous drip. So that the drug delivery rate is equal to the elimination speed of the drug in the body, the distribution of the drug is balanced and then the drug is stopped. At this time, the change of the blood drug concentration only reflects the elimination of the drug, the venous blood is collected at different times, and the elimination half life of the drug is calculated. The results are closer to the actual state of drug elimination in the body.
【作者单位】：西安交通大学医学院药理学系;
【基金】：西安交通大学本科教学改革专题研究项目(2013-27)
【分类号】：R969.1

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