改装滚轮微针用于醋酸曲安奈德经皮给药的特性试验

发布时间：2018-03-05 17:47

本文选题：滚轮微针　切入点：改装　出处：《中国医院药学杂志》2015年04期 　论文类型：期刊论文

【摘要】：目的:评价改装滚轮微针用于曲安奈德经皮给药的力度可控性、释药重现性和皮肤刺激性。方法:改装市售滚轮微针;石蜡切片、HE染色法观察不同微针使用力度(2.5,5.0,7.5,10.0,12.5,15.0,17.5,20.0N)时的皮肤微孔深度,探讨改装前后其力度可控性;以离体裸鼠皮肤为屏障,Franz扩散池法考察改装前后曲安奈德经皮渗透特性;评分法测定皮肤刺激性。结果:皮肤微孔深度随微针使用力度的增加而加大,微孔深度范围由65.28~106.25μm收窄为改装后的71.53~97.92μm,其RSD范围由10.45%~19.69%显著下降至改装后的2.33%~9.21%。在相同微针使用力度下,曲安奈德的累积释药量RSD范围由改装前的34.75%~55.92%,显著下降至改装后的14.29%~29.73%。改装滚轮微针用药1 h时出现轻度皮肤刺激性,之后消失。结论:与市售滚轮微针相比,改装滚轮微针具有较好的力度可控性、释药重现性,以及较小的皮肤刺激性。
[Abstract]:Objective: to evaluate the strength controllability, drug release reproducibility and skin irritation of modified roller microneedle for triamcinolone acetonide. The depth of micropores in different microneedles was observed by HE staining method, and the depth of micropores was studied before and after modification, and the transdermal permeation characteristics of triamcinolone acetonide before and after modification were investigated by Franz diffusion cell method. Results: skin irritation was measured by scoring method. Results: the depth of micropore increased with the increase of the intensity of microneedle use. The depth of micropore narrowed from 65.28 渭 m to 71.53 ~ 97.92 渭 m, and the range of RSD decreased significantly from 10.45 ~ 19.69% to 2.33 ~ 9.21. The range of cumulative release of triamcinolone acetonide (RSD) decreased significantly from 34.7555.92 to 14.29% 29.73. mild skin irritation was observed in the modified roller microneedle for 1 hour, and then disappeared. Conclusion: compared with the marketable roller microneedle, triamcinolone acetonide has a slight skin irritation. The modified roller microneedle has good strength controllability, drug release reproducibility and small skin irritation.
【作者单位】：上海市中医医院药剂科;上海中医药大学附属岳阳医院药剂科;
【分类号】：R943

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