苯酞类化合物的结构分类与生物活性

发布时间：2018-03-06 12:53

本文选题：苯酞　切入点：化学结构　出处：《中国药房》2017年25期 　论文类型：期刊论文

【摘要】：目的:为苯酞类化合物的进一步研究提供参考。方法:以"苯酞""生物活性""共生菌""分离提取""血栓""Phthalide""Biological activity""Isolation and extraction""Thrombus"等为关键词,组合查询2000-2016年在Pub Med、Web of Science、Wiley、中国知网、谷歌学术等数据库中的相关文献,从结构分类、生物活性两方面进行综述。结果与结论:共检索到相关文献209篇,其中有效文献45篇。根据苯酞类化合物C—3和苯环上的取代基不同,将其分为C—3未被取代型苯酞、C—3取代型苯酞、二聚型苯酞、天然类苯酞4种类型。苯酞类化合物具有抑菌、抗肿瘤、抗病毒、杀虫、解热、镇痛及抗炎等生物活性,在保肝、护肾、平喘、降压、改善免疫系统等方面疗效显著。尤其是已应用于临床的几种苯酞类化合物,如那可汀、黄连碱、丁苯酞等,在治疗血栓、脑血管疾病等方面发挥着重要作用。今后还需分离提取出混合物总苯酞中起重要作用的单体苯酞类化合物,进一步研究单体苯酞类化合物的作用机制。
[Abstract]:Objective: to provide a reference for the further study of phthalide compounds. Methods: using phthalide, bioactivity, symbiotic bacteria, Phthalide, Biological activity, Isolation and extraction, Thrombus, etc. The related literatures in Google academic database were reviewed from the aspects of structure classification and biological activity. Results and conclusions: 209 articles were retrieved. According to the different substituents of phthalates C-3 and benzene rings, the compounds were divided into four types: C-3 unsubstituted phthalide, dimer phthalide, natural phthalide. Antitumor, antiviral, insecticidal, antipyretic, analgesic and anti-inflammatory biological activities are effective in protecting liver, protecting kidney, relieving asthma, lowering blood pressure and improving immune system. Coptidine, butylphthalide and so on, play an important role in the treatment of thrombosis, cerebrovascular diseases, etc. In the future, it is necessary to separate and extract monomer phthalide compounds which play an important role in the total phthalide mixture. The mechanism of action of monomer phthalide was further studied.
【作者单位】：兰州交通大学化学与生物工程学院;兰州世创生物科技有限公司;
【基金】：甘肃省科技重大专项计划项目(No.1302NKDA021) 兰州市人才创新创业科技计划项目(No.2014-RC-65) 兰州市科技计划项目(No.2013-4-77)
【分类号】：R914;R96

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