葡萄糖酸盐和1,4-二氧六环水溶液的太赫兹光谱研究

发布时间：2018-03-07 06:36

本文选题：太赫兹光谱技术　切入点：葡萄糖酸盐　出处：《天津大学》2014年硕士论文　论文类型：学位论文

【摘要】：分子的振动和转动往往引起在太赫兹(THz)波段的特征吸收。氢键、范德华力等弱相互作用对分子的构型和物质的结构有着重要影响。而THz波对这些弱相互作用敏感,对多晶型药物、同分异构体、分子衍生物都可很好的区分。这使得THz技术在食品、药品、化学品等检测领域得到广泛应用。水是生命不可缺少的重要物质,作为良溶剂,许多生化反应和生命活动都在水中进行。理解水和物质相互作用对生产生活和人类的认知都有重要意义。水对THz辐射吸收强烈,借助THz波对水的敏感性,开展水与物质相互作用的微观机制研究,是THz技术在生命医学领域应用的重要基础和前提。本课题的工作主要分为以下三个部分一、理解THz波和介质的相互作用理论,依据已报道的物质介电参数提取方法,开发编写了基于Matlab的图形界面(GUI),实现对固体和液体样品的折射率和吸收系数的便捷提取和存储。二、利用太赫兹时域光谱技术(THz-TDS),研究了固体葡萄糖酸盐(Na~+,Mg~(2+),K~+,Ca~(2+),Fe~(2+),Cu~(2+),Zn~(2+))的THz指纹谱;依据朗伯比尔定律,实现多种混合样品的定性和定量分析;利用THz成像技术实现混合样品中不同化合物的成分识别并获得空间分布。结果显示了THz技术在化学药物等检测领域的巨大应用前景。三、以二氧六环-水互溶体系为研究模型,利用THz-TDS技术,研究水与二氧六环分子的相互作用,通过实验测量获得不同浓度二氧六环水溶液在0.2-1.5 THz的介电响应,并对温度效应进行考察。对实验偏离理想吸收模型的内在机制进行分析,获得了二氧六环分子周围壳层水数目,并对二氧六环与水的相互作用进行了探讨。研究结果有助于揭示水与物质相互作用的微观行为。
[Abstract]:The vibration and rotation of molecules often cause characteristic absorption in the THz band. Weak interactions such as hydrogen bonds and van der Waals force have important effects on the configuration and the structure of matter. The THz waves are sensitive to these weak interactions. For polycrystalline drugs, isomers, molecular derivatives can be well distinguished. This makes the THz technology in food, medicine, chemicals and other fields of detection is widely used. Water is an indispensable important substance for life, as a good solvent, Many biochemical reactions and life activities take place in water. Understanding the interaction between water and matter is important to production, life and human cognition. Water absorbs strongly THz radiation and is sensitive to water with the help of THz waves. It is an important foundation and prerequisite for the application of THz technology in the field of life medicine to study the micro mechanism of the interaction between water and matter. The work of this paper is divided into the following three parts to understand the interaction theory of THz wave and medium. According to the reported method of extracting dielectric parameters of materials, a graphical interface based on Matlab is developed to realize the convenient extraction and storage of refractive index and absorption coefficient of solid and liquid samples. In this paper, the THz fingerprint spectra of solid gluconate Na ~ (2 +) MgO _ (2) C ~ (2) C _ (2) C _ (2) C _ (2) C ~ (2 +) (THz _ TDS _ 2) have been studied by using THz time-domain spectroscopy (THz), and the qualitative and quantitative analysis of various mixed samples have been realized according to Lambert's law. The THz imaging technique is used to identify the components of different compounds in the mixed samples and to obtain the spatial distribution. The results show that the THz technique has a great application prospect in the field of chemical drug detection. Third, the dioxane water solution system is used as the research model. The interaction between water and dioxane molecules was studied by THz-TDS technique. The dielectric responses of dioxane aqueous solutions with different concentrations at 0.2-1.5 THz were measured experimentally. The internal mechanism of the experimental deviation from the ideal absorption model was analyzed, and the number of water in the shell around the dioxane molecule was obtained. The interaction between dioxane and water is discussed. The results are helpful to reveal the microscopic behavior of the interaction between water and substance.
【学位授予单位】：天津大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R927;O657.3

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