蛇毒在细胞凋亡线粒体途径中的研究进展

发布时间：2018-03-08 01:37

本文选题：细胞凋亡　切入点：蛇毒　出处：《牡丹江医学院学报》2016年06期 　论文类型：期刊论文

【摘要】：本文简述了细胞凋亡过程中线粒体途径细胞色素C释放的机制,回顾了近年蛇毒对不同肿瘤的作用效果的研究,并归纳了蛇毒抗肿瘤机制线粒体途径的研究。细胞凋亡(apoptosis)是由基因调控的,响应于死亡信号,发生在所有细胞的生理和病理过程,为细胞编程死亡(Programmed cell death,PCD)的方式。细胞凋亡影响着机体疾病的发生发展,凋亡细胞自身发生收缩和凝结,细胞骨架崩溃,核膜拆卸,和核DNA分解成片段。研究发现线粒体是细胞凋亡过程中的关键细胞器之一。多种刺激因子均可引起线粒体的功能障碍。较多数据显示细胞色素C(Cytochrome C,Cyt-C)释放是线粒体途径的关键步骤。蛇毒作为天然药用资源有着许多药用价值,不少研究指出蛇毒可以诱导细胞凋亡且其作用机制可能与线粒体途径有关,而线粒体途径的关键作用步骤是影响细胞色素C(Cyt-C)的释放。
[Abstract]:In this paper, the mechanism of cytochrome C release via mitochondrial pathway during apoptosis was reviewed, and the effects of snake venom on different tumors were reviewed. Apoptosis is regulated by genes and occurs in the physiological and pathological processes of all cells in response to death signals. Apoptosis affects the occurrence and development of body diseases, the contraction and condensation of apoptotic cells themselves, the collapse of cytoskeleton, the dismantling of nuclear membranes. It was found that mitochondria are one of the key organelles in the process of cell apoptosis. Many stimulators can cause mitochondrial dysfunction. More data show that cytochrome cytochrome C (Cyt-C) release is a kind of mitochondria. As a natural medicinal resource, snake venom has a lot of medicinal value. Many studies have shown that snake venom can induce apoptosis and its mechanism may be related to mitochondrial pathway, and the key step of mitochondrial pathway is to influence the release of cytochrome Con Cyt-C.
【作者单位】：皖南医学院基础医学院;
【基金】：安徽省高校省级自然科学重点项目(KJ2014A276)
【分类号】：R99

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