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某综合教学医院利奈唑胺的临床应用适宜性、有效性及安全性分析

发布时间:2018-03-08 02:33

  本文选题:利奈唑胺 切入点:合理用药 出处:《中国医院药学杂志》2017年03期  论文类型:期刊论文


【摘要】:目的:综合评价某综合教学医院住院患者使用利奈唑胺的适宜性、有效性和安全性。方法:采用回顾性研究方法,选取广州市某三甲医院2015年1月-2015年12月使用利奈唑胺注射剂或片剂的患者病例,根据药品说明书和相关指南,分析利奈唑胺的应用情况,并统计有效率及不良反应发生率。结果:共纳入有效病例232例,评价结果合理的有186例(80.17%),不合理的有46例(19.83%);治疗结果痊愈118例(50.86%),显效48例(20.69%),进步21例(9.05%),无效45例(19.40%)。用药后出现不良反应的有69例(29.74%),其中血小板减少50例(21.55%),白细胞减少13例(5.56%),血红蛋白减少9例(3.85%),恶心、呕吐13例(5.56%),腹泻6例(2.56%),皮疹4例(1.71%),乳酸性酸中毒3例(1.28%)。ICU患者血小板减少症的发生率明显高于非ICU患者(P=0.004),但片剂与注射剂、≥65岁与65岁患者间的发生率均无明显差异(P值分别为0.152,0.148)。结论:利奈唑胺治疗革兰阳性球菌感染的疗效较好,但临床应用存在不合理情况,发生血小板减少的比例较高,尤其是ICU患者,值得临床关注。
[Abstract]:Objective: to evaluate synthetically the suitability, efficacy and safety of the use of linazolamide in inpatients of a general teaching hospital. According to the drug instruction and related guidelines, the cases of patients who used linazolamide injection or tablet from January 2015 to December 2015 in a third Class A Hospital of Guangzhou City were selected to analyze the application of linazolamide. The effective rate and incidence of adverse reactions were calculated. Results: 232 effective cases were included. The results of evaluation were reasonable in 186 cases (80.17), unreasonable in 46 cases (19.83), cure in 118 cases (50.86%), remarkable effect in 48 cases (20.6969%), improvement in 21 cases (9.05%), ineffective in 45 cases (19.400.75%), adverse reactions in 69 cases (29.7474%), of which 50 cases had thrombocytopenia (21.55%), and white blood cells (WBC) were decreased in 50 cases (21.55%). 13 cases reduced 5. 56%, 9 cases hemoglobin decreased 3. 85%, nausea, The incidence of thrombocytopenia was significantly higher in 13 patients with vomiting than in non-patients with ICU, but the incidence of thrombocytopenia in 3 patients with lactic acidosis was significantly higher than that in patients without ICU. There was no significant difference in the incidence rate between patients aged 鈮,

本文编号:1582058

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