药物安全性评价新技术和新方法研究进展

发布时间：2018-03-08 15:44

本文选题：药物安全性　切入点：靶器官毒性　出处：《中国医药工业杂志》2017年03期 　论文类型：期刊论文

【摘要】：药物引发的安全性问题一直受到各国药品管理部门广泛而高度的重视,药物安全性评价技术和方法更是各国学者研究的热点。近年来,随着科学技术的不断发展,新的安全性评价技术和方法不断出现,包括肝脏、肾脏、心脏等靶器官毒性,发育和生殖毒性,遗传毒性和致癌性等方面的评价技术和方法。本文主要结合本中心近10年来的研究成果,对药物安全性评价新技术和新方法的研究进展进行了综述。
[Abstract]:The safety problems caused by drugs have been paid more and more attention by the drug administration departments of various countries, and the technology and methods of drug safety evaluation have been the focus of scholars all over the world. In recent years, with the development of science and technology, New safety assessment techniques and methods are emerging, including liver, kidney, heart and other target organ toxicity, developmental and reproductive toxicity, In this paper, the research progress of new techniques and methods for drug safety evaluation was reviewed in the light of the research results of our center in the past 10 years, such as genotoxicity, carcinogenicity, and so on.
【作者单位】：中国医药工业研究总院国家上海新药安全评价研究中心;
【基金】：上海市研发公共服务平台项目(15DZ2290300)
【分类号】：R96

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