莫西沙星在结核性胸膜炎患者体内的药动学及胸膜透过性

发布时间：2018-03-11 01:29

本文选题：莫西沙星　切入点：结核　出处：《中国新药与临床杂志》2017年04期 　论文类型：期刊论文

【摘要】：目的研究莫西沙星在结核性胸膜炎患者血浆及胸水中的药动学,并评价其胸膜透过性。方法 15例结核性胸膜炎患者单剂量口服莫西沙星片0.4 g后,采用高效液相色谱-串联质谱法(HPLC-MS/MS)测定血浆和胸水中莫西沙星的浓度。选用Agilent ZORBAX SB-Aq(150 mm×4.6 mm,5μm)分析柱,以乙腈-5 mmol·L-1醋酸铵水溶液(含0.1%甲酸)为流动相,采用电喷雾离子源(ESI),以正离子多反应监测(MRM)方式进行检测,采用Win Nonlin 6.3软件计算主要药动学参数,并计算莫西沙星的胸膜透过率。结果莫西沙星在血浆和胸水中的主要药动学参数分别为:ρ_(max)(4.10±2.22)和(2.43±1.05)μg·mL~(-1);t_(max)(2.03±1.32)和(3.86±0.24)h;t_(1/2)(9.35±2.22)和(10.02±2.12)h;AUC_(0-t)(31.33±7.13)和(31.58±11.54)h·μg·mL~(-1)。莫西沙星的平均胸膜透过率为101%。结论结核性胸膜炎患者单剂量口服莫西沙星具有胸膜透过性高、峰浓度高和半衰期长的特点。
[Abstract]:Objective to study the pharmacokinetics of moxifloxacin in plasma and pleural effusion of patients with tuberculous pleurisy and to evaluate its pleural permeability. High performance liquid chromatography-tandem mass spectrometry (HPLC-MS / MS) was used to determine the concentration of moxifloxacin in plasma and pleural effusion. The analytical column was Agilent ZORBAX SB-Aq(150 mm 脳 4.6mm-1. The mobile phase was acetonitrile-5 mmol 路L-1 ammonium acetate solution (including 0.1% formic acid). Win Nonlin 6.3 software was used to calculate the main pharmacokinetic parameters. Results the main pharmacokinetic parameters of moxifloxacin in plasma and pleural effusion were: 蟻 maxomax 4.10 卤2.22) and 2.43 卤1.05) 渭 g 路mL ~ (-1). The average pleural permeation rate of moxifloxacin was 101g 路mL ~ (-1) and 3.86 卤0.24 ht ~ (12) 卤2.22 卤2.22) and 10.02 卤2.12 hau / t ~ (0-t) and 31.58 卤11.54 h 路渭 g 路mL ~ (-1) respectively. Conclusion the average pleural permeation rate of moxifloxacin is 101g 路mL ~ (-1). The single dose of moxifloxacin had high pleural permeability. High peak concentration and long half-life.
【作者单位】：中国人民解放军成都军区总医院临床药学科;中国人民解放军成都军区总医院感染呼吸科;
【基金】：四川省科技计划项目(2014JY0149)
【分类号】：R969.1

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