探针药物法评价艾瑞昔布对大鼠CYP2C9酶的影响

发布时间：2018-03-14 13:44

  本文选题：艾瑞昔布　切入点：甲苯磺丁脲　出处：《中国医药工业杂志》2015年02期 　论文类型：期刊论文

【摘要】：利用探针药物法研究艾瑞昔布对大鼠体内CYP2C9酶的影响。将大鼠随机分为试验组和对照组,每组18只,试验组经口灌胃艾瑞昔布,对照组经口灌胃等量蒸馏水,连续给药7 d(2次/d)。d8,每只大鼠经口灌胃甲苯磺丁脲,并于给药后24 h内眼内眦取血,以HPLC法测定血浆药物浓度,拟合药动学参数,并对两组的药动学参数进行统计学分析。结果表明,试验组的AUC0→24 h、AUC0→∞、tmax、CL和V与对照组相比均有显著性差异(P0.05)。合用艾瑞昔布后,甲苯磺丁脲的AUC0→24 h和AUC0→∞显著降低,CL明显增加,表明艾瑞昔布诱导CYP2C9酶的活性,加快甲苯磺丁脲的代谢。
[Abstract]:The effects of alexib on CYP2C9 enzyme in rats were studied by probe drug method. The rats were randomly divided into two groups: the experimental group and the control group, 18 rats in each group. The experimental group was treated by oral administration of eroxib, and the control group was given the same amount of distilled water by oral administration. After 7 days of administration, each rat was given intragastric administration of tolbutylurea, and blood was collected from the medial canthus within 24 hours after administration. Plasma drug concentration was measured by HPLC method, and the pharmacokinetic parameters were fitted. The pharmacokinetic parameters of the two groups were statistically analyzed. The results showed that the AUC0 of the experimental group was higher than that of the control group. 鈫，

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