注射用磷酸特地唑胺体内抗菌作用研究

发布时间：2018-03-15 08:15

本文选题：注射用磷酸特地唑胺　切入点：败血症　出处：《中国抗生素杂志》2017年05期 　论文类型：期刊论文

【摘要】：目的研究注射用磷酸特地唑胺对金黄色葡萄球菌、粪肠球菌、化脓性链球菌的体内抗菌作用。方法选取SPF级ICR小鼠,选用标准菌株金黄色葡萄球菌(ATCC29213)及金黄色葡萄球菌(n=22)、粪肠球菌(n=18)和化脓性链球菌(n=63)3株临床分离的致病菌,以0.5m L最低致死菌量腹腔注射细菌感染小鼠,建立小鼠败血症模型;于造模1h后,分别静脉注射给予不同浓度的注射用磷酸特地唑胺和利奈唑胺注射液药液,记录给药后1~7d小鼠存活数,用BLISS法计算ED50、ED95及P值。结果注射用磷酸特地唑胺对金黄色葡萄球菌标准菌株及3株临床分离的致病菌的ED50值在1.57~3.52mg/kg,ED95值在3.86~8.21mg/kg,均明显优于对照药利奈唑胺注射液(P0.01)。结论注射用磷酸特地唑胺对所测标准菌株及临床分离的致病菌有较好的体内抗菌作用,其作用明显优于同类药利奈唑胺注射液。
[Abstract]:Objective to study the antibacterial effect of terazolamide phosphate on Staphylococcus aureus, Enterococcus faecalis and Streptococcus pyogenes in vivo. Methods SPF grade ICR mice were selected. Three clinical isolates of Staphylococcus aureus ATCC29213), Staphylococcus aureus 22, Enterococcus faecalis 18) and Streptococcus pyogenes were selected. The mice were infected with bacteria at the lowest lethal dose of 0.5 mL, and the septicemia model of mice was established. After 1 hour of modeling, the mice were injected with different concentrations of terazolamide phosphate and linazolamide injection respectively, and the survival number of mice was recorded on the 7th day after administration. Results the values of ED50 ED95 and P were calculated by BLISS method. Results the ED50 value of terazolamine phosphate against Staphylococcus aureus standard strains and three clinical pathogenic bacteria was 1.57 ~ 3.52 mg / kg ED95 at 3.86 ~ 8.21 mg / kg, which was significantly better than that of the control injection (P0.01). Terazolamine phosphate for injection has a good antibacterial effect on the standard strains and clinical pathogenic bacteria. Its effect was obviously superior to that of linazolamide injection.
【作者单位】：南京工业大学;江苏省药物研究所;
【分类号】：R96

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