ICP-MS测定葡萄糖酸钙锌口服溶液中葡萄糖酸锌的含量

发布时间：2018-03-16 06:21

本文选题：葡萄糖酸钙锌口服溶液　切入点：葡萄糖酸锌　出处：《中国执业药师》2016年01期 　论文类型：期刊论文

【摘要】：目的:建立葡萄糖酸钙锌口服溶液中葡萄糖酸锌的含量测定方法。方法:通过对原子吸收分光光度法(AAS)及电感耦合等离子体质谱法(ICP-MS)两种方法测定的葡萄糖酸钙锌口服溶液中葡萄糖酸锌含量结果的比较,证明ICP-MS测定葡萄糖酸钙锌口服溶液中葡萄糖酸锌的方法成立。结果:锌在0~0.8μg/m L浓度范围内线性关系良好(r=0.999 9);平均加样回收率为96.63%(n=5,RSD为1.80%);采用ICP-MS和AAS检测,两种方法的测定结果基本一致。结论:ICP-MS简便、准确、快速、重复性好,为葡萄糖酸钙锌口服溶液葡萄糖酸锌的含量测定提供了有效的方法。
[Abstract]:Objective: to establish a method for the determination of zinc gluconate in calcium gluconate zinc oral solution. Methods: calcium gluconate was determined by atomic absorption spectrophotometry (AAS) and inductively coupled plasma mass spectrometry (ICP-MS). Comparison of the results of zinc gluconate in zinc oral solution, The ICP-MS method for the determination of zinc gluconate in calcium gluconate zinc oral solution was established. Results: the linear relationship of zinc in the concentration range of 0 0. 8 渭 g / mL was good, the average recovery of zinc was 96. 63%, RSD was 1. 80%, ICP-MS and AAS were used to detect zinc. Conclusion the two methods are simple, accurate, rapid and reproducible, which provides an effective method for the determination of zinc gluconate in the oral solution of calcium gluconate and zinc gluconate.
【作者单位】：扬子江药业集团有限公司;
【分类号】：R927.2;O657.63

【相似文献】