质子泵抑制剂泮托拉唑的研究进展

发布时间：2018-03-16 10:11

本文选题：质子泵抑制剂　切入点：泮托拉唑　出处：《中国药房》2016年26期 　论文类型：期刊论文

【摘要】：目的:了解质子泵抑制剂(PPI)泮托拉唑的研究进展。方法:查阅近年来国内外相关文献,就泮托拉唑的作用机制和临床应用的研究进展进行归纳和总结。结果与结论:泮托拉唑通过与胃壁细胞的H+/K+-三磷酸腺苷酶系统的两个位点共价结合而抑制胃酸产生的最后步骤,从而达到抑制胃酸分泌的作用。泮托拉唑对消化性溃疡的治疗效果较第一代PPI更好,且复发率显著降低;在幽门螺杆菌(Hp)感染的胃溃疡治疗中不仅对Hp清除率高,而且能够降低胃溃疡复发率;对消化道出血的临床疗效显著,不良反应少;在反流性食管炎治疗中疗效好、安全、副作用少;可有效改善急性胰腺炎患者临床症状,缩短机体恢复时间,明显降低炎症递质水平,具有较理想的临床疗效及应用价值;可预防创伤后应激性溃疡的发生,对其出血性并发症的疗效好。泮托拉唑临床应用广泛,有必要加大对泮托拉唑临床用药的监控力度。
[Abstract]:Objective: to investigate the research progress of proton pump inhibitor (PPI) pam Tora. Methods: to review the relevant literatures at home and abroad in recent years. The mechanism of pam Tora and its clinical application were summarized and summarized. Results and conclusions: pam Tora inhibited stomach by covalently binding with two sites of H / K triphosphate adenosine system in gastric parietal cells. The final step in acid production, The effect of pam Tora on peptic ulcer was better than that of the first generation of PPI, and the recurrence rate was significantly decreased, and the HP clearance rate was higher in the treatment of gastric ulcer infected by Helicobacter pylori (Helicobacter pylori). In addition, it can reduce the recurrence rate of gastric ulcer, the clinical effect on gastrointestinal hemorrhage is remarkable, and the adverse reactions are less. In the treatment of reflux esophagitis, it has a good effect, safety and less side effects. It can effectively improve the clinical symptoms of patients with acute pancreatitis. Shortening the recovery time and reducing the level of inflammatory transmitters have ideal clinical efficacy and application value, can prevent the occurrence of post-traumatic stress ulcer, and have good curative effect on hemorrhagic complications. It is necessary to strengthen the monitoring of clinical drug use of Pam Tora.
【作者单位】：长沙医学院药学院;湖南九典制药有限公司;
【分类号】：R975

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