抗生素引起细菌体内氧胁迫及其应激响应机制

发布时间：2018-03-20 07:21

本文选题：抗生素　切入点：活性氧(ROS)　出处：《科技通报》2017年03期 　论文类型：期刊论文

【摘要】：抗生素可诱导细菌产生活性氧(ROS)而造成氧化损伤,ROS的积累可以增强抗生素的杀菌效果。因此,抗生素作用下细菌死亡机制除抗生素作用特异性靶点而产生的选择性毒力外,还包括ROS氧化损伤产生的非选择性毒力。细菌通过自身抗氧化系统(OxyR、SoxRS及PerR)的调控机制促进ROS清除、修复氧化损伤以响应抗生素引起的ROS增加。本文对抗生素作用下胞内ROS的产生机制和细菌对氧化损伤的响应机制进行综述。
[Abstract]:Antibiotics can induce bacteria to produce reactive oxygen species (Ros) and cause oxidative damage. The accumulation of Ros can enhance the bactericidal efficacy of antibiotics. Therefore, the mechanism of bacterial death induced by antibiotics is not only the selective virulence produced by specific targets of antibiotics, but also by the accumulation of Ros. It also includes the non-selective virulence produced by oxidative damage of ROS. Bacteria promote ROS scavenging through the regulatory mechanisms of OxyRX RS and Perr. In order to repair oxidative damage in response to the increase of ROS induced by antibiotics, the mechanism of intracellular ROS production and the response of bacteria to oxidative damage were reviewed in this paper.
【作者单位】：浙江工业大学生物工程学院;
【基金】：长三角绿色制药协同创新中心协同科研项目
【分类号】：R978.1

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