米索前列醇晚期引产的临床研究

发布时间：2018-03-20 10:33

本文选题：米索前列醇　切入点：晚期妊娠　出处：《中国临床药理学杂志》2015年21期 　论文类型：期刊论文

【摘要】：目的通过不同剂量、不同时间的米索前列醇阴道给药,观察其在晚期妊娠引产中的临床疗效和安全性,探索米索前列醇阴道用药的剂量和方法。方法180例符合引产指征的足月妊娠妇女随机分为6组,其中5组分别阴道内放置米索前列醇引产,剂量和时间分别为12.5μg q6 h(A组),25μg q6 h(B组),25μg q12 h(C组),50μg q6 h(D组),50μg q12 h(E组),1组为对照组,静脉点滴催产素引产。结果 A组24,48 h引产成功率低于对照组,B、C、D、E组引产成功率均高于对照组(P0.05),4组间差异无统计学意义(P0.05)。A、B、C、D、E组剖宫产率低于对照组,阴道分娩率高于对照组(P0.05);B、C、D、E组产程显著短于对照组(P0.01);B、C组引产48 h成功率差异无统计学意义(P0.05)。结论 25μg q6 h米索前列醇引产成功率高,阴道分娩率高,剖宫产率低且宫缩过强,且不良反应发生率低,为临床值得推荐的剂量和方法。
[Abstract]:Objective to observe the clinical efficacy and safety of misoprostol in the induction of labor in late pregnancy by vaginal administration of misoprostol in different dosage and time. Methods 180 full-term pregnant women who were in accordance with the indication of induced labor were randomly divided into 6 groups, 5 of which were placed misoprostol in vagina to induce labor. The dose and time were 12.5 渭 g / g Q6hU A group (25 渭 g / g Q6hU B) and 25 渭 g / g Q12hU / h / C group respectively, and 50 渭 g / g Q6hU / D group were treated as control group, respectively. Results the successful rate of induced labor in group A was lower than that in control group (P < 0.05). Results the rate of cesarean section in group A was lower than that in group B (P 0.05), and the rate of cesarean section in group A was lower than that in group C (P 0.05). The rate of vaginal delivery was significantly shorter than that of the control group (P 0.05, P 0.05). Conclusion there was no significant difference in the 48 h success rate of induced labor between the two groups. Conclusion the success rate of misoprostol induced labor is high, the vaginal delivery rate is high, the rate of cesarean section is low and the rate of uterine contraction is too strong, the rate of misoprostol induced labor is high at 25 渭 g q6 h, the rate of cesarean section is low and the rate of uterine contraction is too strong. And the incidence of adverse reactions is low, is the clinical recommended dose and method.
【作者单位】：北京市海淀区妇幼保健院产科;
【分类号】：R969.4

【相似文献】