胺碘酮致肺毒性20例文献分析

发布时间：2018-03-21 08:36

本文选题：胺碘酮　切入点：肺毒性　出处：《中国药房》2017年15期 　论文类型：期刊论文

【摘要】：目的:总结应用胺碘酮致肺毒性的一般规律与特点,为临床合理使用胺碘酮及避免相关不良反应发生提供参考。方法:检索中国知网(CNKI)、中文科技期刊数据库(VIP)、万方数据库收录的1990-2016年间发表的胺碘酮致肺毒性相关个案报道文献,对符合要求的病例进行统计和分析。结果:共收集到19篇相关文献,涉及20例应用胺碘酮致肺毒性的患者。其中,年龄60岁的患者占75.0%,男女比例为3∶1;75.0%的患者肺毒性发生时的用药时间1个月;17例患者胺碘酮的口服维持量为200~400mg/d;6例患者死亡,占30.0%。结论:胺碘酮致肺毒性可能与患者的性别、年龄、用药时间、用药剂量等因素有关,其致死率相对较高,应引起广大医务工作者的关注,定期监测,以便及时发现和处理。
[Abstract]:Objective: to summarize the general rules and characteristics of pulmonary toxicity induced by amiodarone. Methods: to provide reference for the rational use of amiodarone in clinic and to avoid the occurrence of related adverse reactions. Methods: to search CNKI, Chinese Journal of Science and Technology database (VIPI), Wanfang database published case reports of amiodarone induced pulmonary toxicity from 1990 to 2016, and to search for the relevant cases of lung toxicity caused by amiodarone. Results: a total of 19 related literatures were collected, involving 20 patients with pulmonary toxicity induced by amiodarone. The age of 60 years was 75.0%, and the male to female ratio of 3: 1% was 75.0%, and the time of taking amiodarone at the time of lung toxicity was 1 month, and the oral maintenance of amiodarone in 17 patients was 200 ~ 400 mg / d, 6 patients died, 30.00.Conclusion: the lung toxicity caused by amiodarone may be related to the patient's sex, age, and age. The death rate is relatively high, which is related to the time and dosage of medication, which should be paid attention to by medical workers and monitored regularly in order to find out and deal with it in time.
【作者单位】：广东省医学科学院/广东省人民医院药学部;
【分类号】：R972

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