砷类化合物致炎性损伤与细胞因子变化的Meta分析

发布时间：2018-03-24 14:15

本文选题：砷　切入点：炎性损伤　出处：《毒理学杂志》2017年03期

【摘要】：目的目前关于砷与炎性损伤的研究结论存在争议,应用Meta分析方法明确二者的关系,为揭示砷毒性作用机制提供参考。方法对中国知网、维普、万方、Cochrane、Pub Med、Springer、Web of Science等数据库进行文献检索,采用Meta分析对近年来国内外发表的实验资料进行分析,以标准化均数差(standard mean difference,SMD)描述组间差别。结果砷干预组IL-6[SMD为2.80,95%CI(1.87,3.72)]、IL-8[SMD为2.72,95%CI(1.63,3.82)]、IL-12[SMD为0.96,95%CI(0.04,1.87)]、NF-κB[SMD为2.76,95%CI(0.36,5.17)]和TNF-α[SMD为2.89,95%CI(2.03,3.75)]均高于对照组(P0.05),IL-10[SMD为-1.13,95%CI(-1.80,-0.46)]和Viability[SMD为-5.27,95%CI(-8.52,-2.02)]均低于对照组(P0.05)。亚组分析可见,高剂量(5μmol/L或5 mg/kg)砷暴露组的IL-2、IL-6、IL-8、NF-κB和TNF-α均高于对照组(P0.05),Viability低于对照组(P=0.01);时间砷暴露(24 h)组的IL-1、IL-6、IL-8、IL-12、NF-κB和TNF-α均高于对照组(P0.05),IL-4、IL-10和Viability均低于对照组(P0.05)。结论砷可以诱发炎性损伤,且高剂量、长时间的砷干预炎性损伤明显。
[Abstract]:Objective to clarify the relationship between arsenic and inflammatory injury by Meta, and to provide a reference for revealing the mechanism of arsenic toxicity. In this paper, the database of Pub Meder of Science and other databases are searched, and the experimental data published at home and abroad in recent years are analyzed by Meta analysis. Results the differences between groups were described by standard mean difference in mean. Results IL-6 [SMD was 2.80995 CI1. 87 / 3.72] IL-8 [SMD was 2. 722 / 95CI1.633 / 3.82] IL-12 [SMD = 0. 9695 CI0.04 / 1.87] NF- 魏 B [SMD = 2. 795 CI0. 36 / 55.17] and TNF- 伪 [SMD = 2. 899 / 95 CI2.033.75] were higher than that of control group P0. 05 [SMD = 1. 1395 CI-1.80-0. 80-0. 46 Viability] and [SMD =-5. 2795 CI0. 36 卤22. 95% -22. 05%] were all lower than those in control group. High dose of 5 渭 mol/L or 5 mg / kg arsenic exposed group was higher than control group in IL-8 IL-8, NF- 魏 B and TNF- 伪. Conclusion arsenic can induce inflammatory injury, and high dose arsenic exposure can induce inflammatory injury, and IL-8 IL-6 IL-12 NF- 魏 B and TNF- 伪 are higher than that of control group. Conclusion arsenic can induce inflammatory injury, and high dose of arsenic can induce inflammatory injury, and the levels of TNF- 伪 and IL-8 IL-12 are higher than those of control group (P 0.05), and the levels of TNF- 伪 are higher than those of control group (P 0.05). Conclusion arsenic can induce inflammatory injury, and the concentration of TNF- 伪 in arsenic exposure group is higher than that in control group (P < 0.05). Long-term arsenic intervention in inflammatory injury was obvious.
【作者单位】：石河子大学医学院预防医学系;
【基金】：国家自然基金(81560517) 兵团应用基础研究(2015AG014) 兵团科技领域重点攻关项目(2014BA039) 石河子大学国际合作项目(GJHZ201602)
【分类号】：R99

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