控制抗菌药物的应用对住院新生儿预后的影响

发布时间：2018-03-26 05:51

本文选题：新生儿　切入点：抗菌药物　出处：《中国抗生素杂志》2015年04期

【摘要】：目的探讨控制抗菌药物应用对住院新生儿病情转归的影响。方法采用回顾性调查方法,将我院新生儿一病房2010年6月与2013年6月住院患儿分为控制前、后2组,并按《新生儿危重病例评分法(草案)》分别将其分为非危重组及危重组,对其抗菌药物应用情况及预后转归进行分析。结果控制后抗菌药物应用率减少21.36%[100%(244/244)vs 78.62%(261/332),χ2=226.4,P0.001,联用药率减少66.8%[90.5%(220/243)vs 23.8%(62/261),χ2=227.7,P0.001],平均抗菌药物用药频度(DDDs)减少18.66%,但住院期间感染反复或加重、出院转归、住院天数及发生感染严重并发症两组比较均无统计学差异(P0.05)。结论控制抗菌药物应用后明显减少抗菌药物使用率,且未增加患儿住院期间感染负担,未改变临床转归。
[Abstract]:Objective to investigate the effect of antimicrobial control on the prognosis of hospitalized neonates. Methods the first ward of newborn in our hospital in June 2010 and June 2013 were divided into two groups: before and after control. According to the "critical Neonatal case scoring method (draft)", it was divided into non-critical reorganization and critical reorganization, Results after control, the antimicrobial application rate was reduced by 21.36% [100%(244/244)vs 78.62% 26.1 / 332U, 蠂 2 226.4% P 0.001, combined drug use rate decreased 66.8% [90.5%(220/243)vs 23.80.62 / 261, 蠂 2227.7% P0.001], average antimicrobial use frequency and DDDsdecreased 18.66%, but the infection was repeated or aggravated during hospitalization, and the discharge rate was reduced. There was no significant difference between the two groups in the days of hospitalization and the serious complications of infection (P0.050.Conclusion the utilization rate of antimicrobial agents was significantly reduced after the control of antimicrobial agents, and the burden of infection was not increased and the clinical outcome was not changed.
【作者单位】：重庆医科大学附属儿童医院新生儿中心儿童发育疾病研究省部共建教育部重点实验室儿科学重庆市重点实验室重庆市儿童发育重大疾病诊治与预防国际科技合作基地;浙江医科大学附属儿童医院;
【基金】：国家自然科学基金资助项目(No.81370744) 国家临床重点专科建设项目经费资助(卫办医政函2011-873) “十二五”国家科技支撑计划项目之课题五(No.2012BAI04B05)
【分类号】：R969.3

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