基于酶敏感机制的可激活细胞穿透肽在靶向输送系统中的应用

发布时间：2018-03-29 19:41

  本文选题：细胞穿透肽　切入点：可激活细胞穿透肽　出处：《药学学报》2015年02期

【摘要】：细胞穿透肽的细胞膜穿透作用借助于一种非选择性和受体非依赖性的方式。该特点使得细胞穿透肽介导的细胞摄取过程适用于较广泛的细胞类型,而这种普遍性对于癌症治疗和诊断领域的应用无疑是重大障碍。因此,将体循环给药的细胞穿透肽惰化形式在肿瘤等病变区域选择性地转变为活化态成为研究热点。本文重点关注引入酶敏感机制的可激活细胞穿膜肽及其靶向递送系统,对此类传递载体的研究概况进行综述。
[Abstract]:The cell penetrating action of cell penetrating peptides is mediated by a non-selective and receptor-independent approach, which makes the cellular uptake process mediated by cellular penetrating peptides suitable for a wide range of cell types. This universality is no doubt a major obstacle to the application of cancer treatment and diagnosis. The selective transformation of cellular penetrating peptide inerting form of systemic circulation drug into active state in tumor and other pathological regions has become a hot topic. This paper focuses on the activated cellular membrane penetrating peptide and its targeted delivery system, which can be activated by introducing the enzyme sensitive mechanism. The research situation of this kind of carrier is reviewed.
【作者单位】： 河北医科大学药学院;北京大学药学院;
【基金】：国家自然科学基金资助项目(81302725,81273454) 国家“重大新药创制”科技重大专项资助项目(2013ZX09402103)
【分类号】：R943
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本文编号：1682572