有机膜表面的纳米加工及其抑菌性研究

发布时间：2018-04-02 08:16

本文选题：多元共轭不饱和脂肪酸有机薄膜　切入点：纳米银单质及CLn-Ag有机涂层　出处：《河南师范大学》2014年硕士论文

【摘要】：本论文中，我们在之前成功合成石榴酸的基础上，通过挥发的方法在玻璃片上制备出了石榴酸——碳链长度为十八，含有一个共轭三烯（9顺,11反,13顺）的长链脂肪酸（CLn）的有机薄膜。此外，通过在CLn有机薄膜表面吸附具有抑菌性的纳米银、纳米氧化锌和纳米氧化镁，制备出表面修饰的CLn-Ag、CLn-MgO和CLn-ZnO有机涂层并对其抑菌作用进行评价。主要开展研究的工作包括以下几个方面：（1） CLn有机薄膜的制备及其表征，对其抑菌性进行测试。CLn有机薄膜无论是对大肠杆菌还是金黄色葡萄球菌均显示出良好的抑菌性。（2）纳米银在CLn有机薄膜表面的附着，所得CLn-Ag有机涂层的性质表征及其抑菌性的测试。扫描电镜，高倍透镜，XRD及能谱结果均证明附着在有机薄膜上的颗粒物为纳米银颗粒。在分别对大肠杆菌和金黄色葡萄球菌的抑菌试验中，CLn有机薄膜与附着上的银纳米颗粒均显示出一定的协同作用。这一性质将促使CLn-Ag有机涂层作为生物材料应用于组织工程。（3）纳米氧化镁的制备及其在CLn有机薄膜表面的附着，所得CLn-MgO有机涂层的性质表征及其抑菌性测试。表征结果显示附着在CLn有机薄膜上的颗粒物为氧化镁纳米颗粒，，但对大肠杆菌及金黄色葡萄球菌的抑菌试验中，附着的氧化镁纳米颗粒抑制了CLn有机薄膜的抑菌性，同时，氧化镁纳米颗粒本身的抑菌活性也没有显示。（4）纳米氧化锌的制备及其在CLn有机薄膜表面的附着，所得CLn-ZnO有机涂层的性质表征及其抑菌性测试。表征结果显示附着在CLn有机薄膜上的颗粒物为氧化锌纳米颗粒，但对大肠杆菌及金黄色葡萄球菌的抑菌试验中，氧化锌纳米颗粒与CLn有机薄膜在抑菌性方面，对大肠杆菌有拮抗作用，对金黄色葡萄球菌有协同作用。
[Abstract]:In this paper, on the basis of the successful synthesis of pomegranate, we prepared pomegranate on glass by volatilization method. The length of pomegranate-carbon chain is 18. Organic thin films containing a conjugated triene 9, cis 11, reverse 13 cis).; in addition, by adsorbing bacteriostasis nano silver, nanometer zinc oxide and nano magnesium oxide on the surface of the CLn organic film, The surface modified CLn-ZnO and CLn-MgO organic coatings were prepared and their bacteriostatic effects were evaluated. 1) preparation and characterization of CLn organic films. The bacteriostatic properties of CLn organic films were tested. Both Escherichia coli and Staphylococcus aureus showed good bacteriostasis. (2) the adhesion of nano-silver on the surface of CLn organic film, the characterization of the properties of the obtained CLn-Ag organic coating and the test of its bacteriostasis. The results of X-ray diffraction (XRD) and energy dispersive spectrum (EDS) of high power lens show that the particles attached to the organic film are silver nanoparticles. In the bacteriostasis test of Escherichia coli and Staphylococcus aureus respectively, the silver nanoparticles attached to the organic film and the CLn film are the same. This property will promote the application of CLn-Ag organic coatings as biomaterials in tissue engineering. (3) preparation of nano-MgO and its adhesion on the surface of CLn organic film, characterization and bacteriostatic test of the obtained CLn-MgO organic coating. The characterization results showed that the particles attached to the CLn organic film were magnesium oxide nanoparticles. However, in the bacteriostatic test of Escherichia coli and Staphylococcus aureus, the bacteriostasis of CLn organic film was inhibited by the attached magnesium oxide nanoparticles, and the bacteriostatic activity of magnesium oxide nanoparticles itself was not shown. (4) preparation of nano-ZnO and its adhesion on the surface of CLn organic film, characterization and bacteriostatic test of the obtained CLn-ZnO organic coating. The characterization results showed that the particles attached to CLn organic film were ZnO nanoparticles. However, in the bacteriostatic test of Escherichia coli and Staphylococcus aureus, zinc oxide nanoparticles and CLn film had antagonistic effect on Escherichia coli and synergistic effect on Staphylococcus aureus.
【学位授予单位】：河南师范大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R96;O647

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