VanC型肠球菌与屎肠球菌对常用抗菌药的耐药状况研究

发布时间：2018-04-03 11:20

本文选题：Van　切入点：C型肠球菌　出处：《中国临床药理学杂志》2015年01期

【摘要】：目的比较Van C型肠球菌及屎肠球菌对常用抗菌药物的敏感性。方法针对56株Van C型肠球菌及299株屎肠球菌,用琼脂二倍稀释法进行药物敏感性分析;检测高水平耐万古霉素屎肠球菌的万古霉素耐药基因型。结果Van C型肠球菌万古霉素最低抑菌浓度(MIC)众数为4 mg·L-1,未发现对氨苄西林、万古霉素、替考拉宁及利奈唑胺耐药的Van C型肠球菌。屎肠球菌对氨苄西林、左氧氟沙星、红霉素及利福平的耐药率均达85%以上;对万古霉素和替考拉宁的耐药率分别为1.7%和0.7%;未发现对利奈唑胺和替加环素耐药的屎肠球菌。屎肠球菌万古霉素MIC众数为0.5 mg·L-1。5株万古霉素屎肠球菌万古霉素耐药基因均为van A型。结论屎肠球菌对万古霉素尚保持较高敏感性,万古霉素对Van C型肠球菌最低抑菌浓度较屎肠球菌高。
[Abstract]:Objective to compare the susceptibility of Van C Enterococcus and Enterococcus faecium to common antimicrobial agents.Methods the susceptibility of 56 strains of Enterococcus Van C and 299 strains of Enterococcus faecium were analyzed by Agar double dilution method, and the vancomycin resistant genotypes of high level vancomycin resistant Enterococcus faecium were detected.Results the lowest inhibitory concentration of vancomycin in Enterococcus Van C was 4 mg / 1. No enterococcus Van C was found to be resistant to ampicillin, vancomycin, teicoplanin and linazolamine.The resistance rates of Enterococcus faecium to ampicillin levofloxacin erythromycin and rifampicin were over 85% and to vancomycin and teicoplanin were 1.7% and 0.7 respectively.The vancomycin resistant genes of Enterococcus faecium (MIC) were all van A type. The MIC mode of vancomycin was 0.5 mg L ~ (- 1. 5).Conclusion Enterococcus faecium is still sensitive to vancomycin, and the minimum inhibitory concentration of vancomycin against Van C Enterococcus is higher than that of Enterococcus faecium.
【作者单位】：北京大学第一医院临床药理研究所;
【基金】：国家自然科学基金面上基金资助项目(81171612) 国家科技支撑计划基金资助项目(2012EP001000)
【分类号】：R96

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