难溶性药物姜黄素作为纳米晶稳定剂制备Pickering乳剂的研究

发布时间：2018-04-04 03:26

本文选题：姜黄素　切入点：Pickering乳剂　出处：《中草药》2017年09期

【摘要】：目的使用姜黄素纳米晶(curcumin nanocrystalline,Cur-NC)作为固体颗粒稳定剂,制备Cur-NC自稳定Pickering乳剂(Cur-NC self-stabilized Pickering emulsion,Cur-NCSPE)。方法采用高压均质机制备Cur-NCSPE;比较不同的均质压力对Cur-NC粒径的影响,考察Cur-NC的加入量对Cur-NCSPE形成的影响,用光学显微镜、扫描电子显微镜观察乳剂的形态与结构,对Cur-NCSPE的稳定性及体外药物释放进行考察。结果随着高压均质压力的增加,Cur-NC的粒径逐渐减小,当高压均质压力大于100 MPa后,Cur-NC的粒径变化趋于平稳;随着姜黄素(curcumin,Cur)投入量的增加,Cur-NC对油滴的包裹量增大,乳滴的粒径逐渐减小,当加入的药物量能够将油滴完全包裹时,继续增大药物量对乳滴粒径的影响不再明显。Cur-NCSPE的稳定性比Cur-NC和Cur高,Cur-NCSPE的体外释放速率比Cur-NC和Cur的释放速率显著加快。结论成功制备了Cur-NCSPE,有望为中药难溶性成分提供新的口服给药技术平台。
[Abstract]:Objective to prepare Cur-NC self-stable Pickering emulsion Cur-NC self-stabilized Pickering emulsionCur-NCSPEE using curcumin nanocrystalline Cur-NCas as solid particle stabilizer.Methods Cur-NCSPEs were prepared by high pressure homogenizer, the effect of different homogenization pressure on the particle size of Cur-NC was compared, the effect of Cur-NC addition on the formation of Cur-NCSPE was investigated, and the morphology and structure of emulsion were observed by optical microscope and scanning electron microscope.The stability of Cur-NCSPE and drug release in vitro were investigated.Results with the increase of high pressure homogenization pressure, the particle size of Cur-NC gradually decreased, when the pressure of high pressure was more than 100 MPa, the particle size of Cur-NC tended to be stable, and with the increase of the amount of curcumin (Curcumin Curn), the amount of oil droplet encapsulated by Cur-NC increased.The size of the emulsion droplets decreases gradually, and when the amount of the added drug is able to completely encapsulate the oil droplets,The stability of Cur-NCSPE was higher than that of Cur-NC and Cur. The release rate of Cur-NCSPE in vitro was significantly faster than that of Cur-NC and Cur.Conclusion Cur-NCSPEhas been successfully prepared, which is expected to provide a new platform for oral administration of insoluble components of traditional Chinese medicine.
【作者单位】：重庆医科大学药学院重庆高校药物工程研究中心;
【基金】：重庆市自然科学基金资助项目(cstc2016jcyjA0068)
【分类号】：R943

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