甘草酸二铵二元脂质体温敏凝胶的制备及其体外释药行为

发布时间：2018-04-04 04:10

  本文选题：甘草酸二铵　切入点：二元脂质体　出处：《中成药》2017年11期

【摘要】：目的制备甘草酸二铵二元脂质体温敏凝胶,并评价其体外释药行为。方法冷溶法制备凝胶。以胶凝温度为评价指标,泊洛沙姆407(P407)、泊洛沙姆188(P188)、白芨多糖用量为影响因素,星点设计-效应面法优化处方。再采用HPLC和Franz立式扩散池法评价其体外释药行为。结果最优处方为P407用量18%,P188用量4%,多糖用量0.6%,胶凝温度(37.5±0.3)℃。所得二元脂质体温敏凝胶在48 h内的累积释放率为(65.52±0.63)%,与脂质体及温敏凝胶相比缓释作用更明显。结论甘草酸二铵二元脂质体温敏凝胶可减缓药物在直肠内的释放速率,并增加其滞留时间。
[Abstract]:Objective to prepare diammonium glycyrrhizinate binary lipid thermo-sensitive gel and evaluate its drug release behavior in vitro.Methods Gel was prepared by cold dissolution method.The gelation temperature was taken as the evaluation index, Poloxamer 407, Poloxamer 188 P188, and the amount of Bletilla striata polysaccharides as the influencing factors, and the star design-effect surface method was used to optimize the formulation.Then HPLC and Franz vertical diffusion cell were used to evaluate the drug release behavior in vitro.Results the optimum prescription was: P407 18: P188 4, polysaccharide 0.610, gelation temperature 37.5 卤0.3 鈩，

本文编号：1708308