39例新生儿万古霉素血药浓度监测与用药分析

发布时间：2018-04-05 00:25

  本文选题：万古霉素　切入点：新生儿　出处：《中国医院药学杂志》2015年03期

【摘要】：目的:评价万古霉素在新生儿的临床应用及其血药浓度监测情况,为临床合理用药提供参考。方法:采用回顾性分析方法,收集2012-2013年在新生儿使用万古霉素治疗并进行血药浓度监测的39例,对其疾病分布、病原学检查、PCT检测、药物敏感试验、用药天数、药物疗效、合并用药、肝肾功能等指标进行统计分析。结果:39例患儿中临床第一诊断为新生儿肺炎者比例最高,为29例(74.36%);病原学送检率100%,阳性检出率69.2%;药物敏感试验显示对万古霉素高度敏感的占77.78%;PCT送检率97.44%;万古霉素血药谷浓度范围在15~20μg·ml-1的为19.05%;平均用药时间(12.4±4.9)d;联合应用2种抗菌药物的比例为84.62%;抽样患儿使用万古霉素治疗的有效率为89.7%。结论:新生儿使用万古霉素治疗由革兰阳性菌引起的重症感染疗效确切,但应进行血药浓度(谷浓度)监测,使其血药浓度维持在安全有效范围内,以提高用药的安全性和有效性。
[Abstract]:Objective: to evaluate the clinical application of vancomycin in neonates and to provide reference for rational use of vancomycin.Methods: a retrospective analysis was carried out on 39 newborns who were treated with vancomycin and monitored their blood drug concentrations in 2012-2013. The disease distribution, etiological examination, PCT test, drug sensitivity test, drug use days, and drug efficacy were analyzed.Combined use of drugs, liver and kidney function and other indicators for statistical analysis.Results among 39 cases, the proportion of newborns with pneumonia was the highest.涓，

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