透皮肽TD1调节达卡巴嗪纳米柔性脂质体的透皮特性研究

发布时间：2018-04-05 12:13

  本文选题：生物医学工程　切入点：透皮增强肽TD　出处：《中国科技论文》2017年12期

【摘要】：将黑色素瘤治疗药物达卡巴嗪包裹到纳米柔性脂质体中,并通过透皮增强肽TD1调节达卡巴嗪纳米柔性脂质体颗粒透皮。采用薄膜水化法,制备了达卡巴嗪纳米柔性脂质体,通过考察溶液的外观、粒子粒径和包封率,表征达卡巴嗪纳米柔性脂质体的各项性能。最后分别考察了达卡巴嗪纳米柔性脂质体的透皮和透皮增强肽TD1调控的达卡巴嗪纳米柔性脂质体的透皮。结果表明:达卡巴嗪纳米柔性脂质体粒径分布较为均一且不聚集,脂质体能够较好地促进达卡巴嗪透皮;达卡巴嗪纳米柔性脂质体与透皮增强肽TD1协同使用,能够进一步促进达卡巴嗪的透皮。
[Abstract]:The drug of melanoma treatment was encapsulated into the nano-flexible liposome, and the transdermal enhancement peptide TD1 was used to regulate the transdermal penetration of the dacarbazine nano-flexible liposome particles.Dacarbazide nano-flexible liposomes were prepared by membrane hydration. The properties of dacarbazide nano-flexible liposomes were characterized by investigating the appearance, particle size and encapsulation efficiency of the solution.Finally, the transdermal transdermal and transdermal transdermal effects of dacarbazide nano-flexible liposomes regulated by transdermal enhancement peptide (TD1) were investigated respectively.The results showed that the diameter distribution of dacarbazide nano-flexible liposomes was uniform and non-aggregation, and the liposome could promote the transdermal penetration of Dhakabaxine, and the dacarbazide nano-flexible liposomes were used in combination with transdermal enhancement peptide (TD1).It can further promote the transdermal penetration of dacabaxine.
【作者单位】： 中国科学技术大学信息科学与技术学院;
【基金】：高等学校博士学科点专项科研基金资助项目(20133402120033) 国家自然科学基金资助项目(81571768)
【分类号】：R943
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本文编号：1714711