苯磺酸氨氯地平叶酸片在健康人体药代动力学研究

发布时间：2018-04-09 19:35

  本文选题：苯磺酸氨氯地平叶酸片　切入点：药代动力学　出处：《中国临床药理学杂志》2015年15期

【摘要】：目的研究健康受试者单剂量口服苯磺酸氨氯地平叶酸片和苯磺酸氨氯地平的药代动力学。方法用自身对照、三周期、拉丁方交叉试验设计。24名健康受试者单剂量口服苯磺酸氨氯地平叶酸片(5.4 mg),苯磺酸氨氯地平叶酸片(5.8 mg)或苯磺酸氨氯地平片(5 mg),用LC-MS/MS法测定血浆中氨氯地平,计算其主要药代动力学参数。用DAS软件对主要药代动力学参数进行比较。结果苯磺酸氨氯地平叶酸片(5.4 mg)、苯磺酸氨氯地平叶酸片(5.8 mg)和苯磺酸氨氯地平片(5 mg)中氨氯地平的主要药代动力学参数:AUC0-t分别为(115.30±28.12),(119.42±32.80),(113.19±27.08)ng·m L-1·h;Cmax分别为(2.59±0.60),(2.59±0.50),(2.56±0.59)ng·m L-1;t1/2分别为(38.90±9.27),(33.85±11.31),(40.66±7.05)h。结论 3种药物的主要药代动力学参数无显著性差异。
[Abstract]:Objective to study the pharmacokinetics of amlodipine benzenesulfonic acid tablets and amlodipine benzenesulfonate tablets in healthy volunteers.Methods Self-control, three cycles,Latin square cross test design. 24 healthy volunteers were given amlodipine benzenesulfonic acid tablets (5.4 mg / g), amlodipine benzenesulfonate tablets (5.8 mg / L) or amlodipine benzenesulfonate tablets (5 mg / g). Amlodipine in plasma was determined by LC-MS/MS method.The main pharmacokinetic parameters were calculated.The main pharmacokinetic parameters were compared with DAS software.缁撴灉鑻�纾洪吀姘ㄦ隘鍦板钩鍙堕吀鐗�(5.4 mg),鑻�纾洪吀姘ㄦ隘鍦板钩鍙堕吀鐗�(5.8 mg)鍜岃嫰纾洪吀姘ㄦ隘鍦板钩鐗，

本文编号：1727841