醋酸氯己定乳膏的质量标准研究

发布时间：2018-04-11 03:18

本文选题：醋酸氯己定乳膏 + 薄层色谱法　；参考：《中国药房》2015年15期

【摘要】：目的:为建立醋酸氯己定乳膏的质量标准提供参考。方法:增订醋酸氯己定乳膏中冰片的薄层色谱鉴别;建立高效液相色谱法测定醋酸氯己定含量的方法。结果:冰片薄层色谱斑点清晰,可用于鉴别;醋酸氯己定质量浓度在10.02~160.30μg/ml范围内与峰面积呈良好的线性关系(r=0.999 7);精密度、稳定性、重复性试验的RSD均1.0%;回收率为100.9%,RSD为1.9%(n=9)。结论:该方法方便、快捷、重复性好,可作为醋酸氯己定乳膏的质量控制方法。
[Abstract]:Objective: to establish the quality standard of chlorhexidine acetate cream.Methods: to update the TLC identification of borneol in chlorhexidine acetate cream and to establish a HPLC method for the determination of chlorhexidine acetate.Results: the dot of borneol thin layer chromatography was clear and could be used for identification, the linear relationship between chlorhexidine acetate concentration and peak area was good in the range of 10.02 渭 g/ml and 160.30 渭 g/ml, the RSD of precision, stability and repeatability was 1.0%, and the recovery was 100.9%.Conclusion: the method is convenient, rapid and reproducible, and can be used as a quality control method for chlorhexidine acetate cream.
【作者单位】：广州军区联勤部药品仪器检验所;南方医科大学药学院;
【基金】：军队医疗机构制剂标准提高科研专项课题(No.13ZJZ19-3)
【分类号】：R927.1

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