姜黄素微球中药物存在形式与释药行为的关系研究

发布时间：2018-04-11 09:13

本文选题：姜黄素 + 聚乳酸-羟基乙酸共聚物　；参考：《药学学报》2016年01期

【摘要】：为了研究姜黄素微球中药物的存在形式及其与微球释药行为的关系,本文以聚乳酸-羟基乙酸共聚物(PLGA)为载体材料,使用SPG(shirasu porous glass)膜乳化装置制备了高、中、低3种载药量的姜黄素微球,并使用高效液相色谱法(HPLC)对3批微球的体外释放情况进行了研究。利用扫描电镜(SEM)对3批微球的形貌进行了观察,同时利用X-射线粉末衍射(XRD)、差示扫描量热仪(DSC)和红外光谱(IR)对微球中姜黄素的存在形式进行研究。制备的3批微球的载药量分别为(5.85±0.21)%、(11.71±0.39)%和(15.41±0.40)%,姜黄素与PLGA之间并未发生化学连接。在载药量最低的微球中,姜黄素以无定形的非晶体状态分散在PLGA中,但载药量较高的两批微球中分别出现(2.12±0.64)%和(5.66±0.07)%药物结晶。结果发现,不同载药量的微球中姜黄素的存在形式不尽相同,同时这种区别也导致了3批微球的体外释放呈现梯度式差异。
[Abstract]:In order to study the forms of curcumin microspheres and their relationship with the drug release behavior of microspheres, high and moderate concentrations were prepared by using SPG(shirasu porous glass-membrane emulsifier with poly (lactic acid-glycolic acid) copolymers as carrier materials.The release in vitro of three batches of curcumin microspheres with low drug loading was studied by high performance liquid chromatography (HPLC).The morphology of three batches of microspheres was observed by scanning electron microscopy (SEM), and the forms of curcumin in microspheres were studied by means of X-ray powder diffraction (XRD), differential scanning calorimetry (DSC) and infrared spectroscopy (IR).The drug loading of the three batches of microspheres were 5.85 卤0.21, 11.71 卤0.39% and 15.41 卤0.40%, respectively. There was no chemical connection between curcumin and PLGA.In the microspheres with the lowest drug loading, curcumin was dispersed in the amorphous state of PLGA, but in the two batches of microspheres with higher drug loading, the crystals were 2.12 卤0.64% and 5.66 卤0.07%, respectively.The results showed that the forms of curcumin in the microspheres loaded with different amounts of drugs were different, and this difference also led to the gradient difference in the release of three batches of microspheres in vitro.
【作者单位】：广东药学院药科学院;广东药学院医药化工学院;
【基金】：广东省科技厅重大项目资助项目(2011A080504003)
【分类号】：R943

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